Rabbit anti-Human PECI Polyclonal Antibody | anti-PECI antibody
PECI (Delta(3),delta(2)-enoyl-CoA Isomerase, Diazepam-binding Inhibitor-related Protein 1, D3,D2-enoyl-CoA Isomerase, Dodecenoyl-CoA Isomerase, DRS1, DRS-1, HCA88, Hepatocellular Carcinoma-associated Antigen 88, KIAA0536, pECI, Peroxisomal 3,2-trans-enoyl
Gene Names
ECI2; DRS1; PECI; ACBD2; DRS-1; HCA88; dJ1013A10.3
Reactivity
Human
Applications
Western Blot
Purity
Purified by Protein A Affinity Chromatography.
Synonyms
PECI; Polyclonal Antibody; PECI (Delta(3); delta(2)-enoyl-CoA Isomerase; Diazepam-binding Inhibitor-related Protein 1; D3; D2-enoyl-CoA Isomerase; Dodecenoyl-CoA Isomerase; DRS1; DRS-1; HCA88; Hepatocellular Carcinoma-associated Antigen 88; KIAA0536; pECI; Peroxisomal 3; 2-trans-enoyl; anti-PECI antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human PECI.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Applicable Applications for anti-PECI antibody
Western Blot (WB)
Application Notes
Applications are based on unconjugated antibody.
Immunogen
Full-length human PECI, aa1-364 (NP_006108.2).
Immunogen Sequence
MNRTAMRASQKDFENSMNQVKLLKKDPGNEVKLKLYALYKQATEGPCNMPKPGVFDLINKAKWDAWNALGSLPKEAARQNYVDLVSSLSPSLESSSQVEPGTDRKSTGFETLVVTSEDGITKIMFNRPKKKNAINTEMYHEIMRALKAASKDDSIITVLTGNGDYYSSGNDLTNFTDIPPGGVEEKAKNNAVLLREFVGCFIDFPKPLIAVVNGPAVGISVTLLGLFDAVYASDRATFHTPFSHLGQSPEGCSSYTFPKIMSPAKATEMLIFGKKLTAGEACAQGLVTEVFPDSTFQKEVWTRLKAFAKLPPNALRISKEVIRKREREKLHAVNAEECNVLQGRWLSDECTNAVVNFLSRKSKL
Conjugate
AP
Note
Preservative Free
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Western Blot (WB)
(Western Blot analysis of PECI expression in transfected 293T cell line by PECI polyclonal antibody. Lane 1: PECI transfected lysate (40.2kD). Lane 2: Non-transfected lysate.)
Related Product Information for anti-PECI antibody
PECI, also referred to as DRS1, ACBD2 or HCA88, is a protein that localizes to the peroxisomal matrix and contains one ACB (acyl-CoA-binding) domain. This protein is expressed abundantly in liver, heart and skeletal muscle. It functions to catalyze the isomerization of both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species, playing an important role in the b-oxidation of unsaturated fatty acids.
Product Categories/Family for anti-PECI antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
39,609 Da
NCBI Official Full Name
enoyl-CoA delta isomerase 2, mitochondrial isoform 1
NCBI Official Synonym Full Names
enoyl-CoA delta isomerase 2
NCBI Official Symbol
ECI2
NCBI Official Synonym Symbols
DRS1; PECI; ACBD2; DRS-1; HCA88; dJ1013A10.3
NCBI Protein Information
enoyl-CoA delta isomerase 2, mitochondrial; DBI-related protein 1; dodecenoyl-CoA isomerase; D3,D2-enoyl-CoA isomerase; renal carcinoma antigen NY-REN-1; delta(3),delta(2)-enoyl-CoA isomerase; peroxisomal D3,D2-enoyl-CoA isomerase; peroxisomal 3,2-trans-e
UniProt Protein Name
Enoyl-CoA delta isomerase 2, mitochondrial
UniProt Gene Name
ECI2
UniProt Synonym Gene Names
DRS1; HCA88; PECI; D3,D2-enoyl-CoA isomerase; DBI-related protein 1; pECI
UniProt Entry Name
ECI2_HUMAN
NCBI Description
This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011]
Uniprot Description
PECI: Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Lipid Metabolism - fatty acid; Isomerase; EC 5.3.3.8
Chromosomal Location of Human Ortholog: 6p24.3
Cellular Component: nucleoplasm; peroxisomal matrix; membrane; intracellular membrane-bound organelle; mitochondrion
Molecular Function: acyl-CoA binding; dodecenoyl-CoA delta-isomerase activity; receptor binding
Biological Process: metabolic process; fatty acid catabolic process
