Rabbit PEAR1 Polyclonal Antibody | anti-PEAR1 antibody

PEAR1 Antibody

Cat. Num. AAA9629570

• Gene Names: PEAR1; JEDI; MEGF12
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: PEAR1; Polyclonal Antibody; PEAR1 Antibody; hPEAR1; JEDI; MEGF12; Multiple EGF-like domains protein 12; Multiple epidermal growth factor-like domains protein 12; Pear1; PEAR1_HUMAN; Platelet endothelial aggregation receptor 1; RP11-107D16.3; anti-PEAR1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: PEAR1 Antibody detects endogenous levels of total PEAR1.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-PEAR1 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: Belongs to the MEGF family.
• Post Translational Modifications: Phosphorylated in the intracellular domain on tyrosine residues (By similarity). Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2.
• Subunit Structure: Interacts with SHC2 upon its aggregation-induced tyrosine phosphorylation.
• Tissue Specificity: Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages.
• Function: When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.
• Note: Detected on the cell surface in resting platelets.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-PEAR1 antibody

Cell membrane; Single-pass membrane protein; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 122937343
• NCBI GeneID: 375033
• NCBI Accession #: NP_001073940
• NCBI GenBank Nucleotide #: NM_001080471.1
• UniProt Accession #: Q5VY43; Q8TEK2
• Molecular Weight: 110,666 Da
• NCBI Official Full Name: platelet endothelial aggregation receptor 1
• NCBI Official Synonym Full Names: platelet endothelial aggregation receptor 1
• NCBI Official Symbol: PEAR1
• NCBI Official Synonym Symbols: JEDI; MEGF12
• NCBI Protein Information: platelet endothelial aggregation receptor 1; hPEAR1; multiple EGF-like-domains 12; multiple EGF-like domains protein 12; multiple epidermal growth factor-like domains protein 12
• UniProt Protein Name: Platelet endothelial aggregation receptor 1
• Protein Family: Platelet endothelial aggregation receptor
• UniProt Gene Name: PEAR1
• UniProt Synonym Gene Names: MEGF12; hPEAR1; Multiple EGF-like domains protein 12
• UniProt Entry Name: PEAR1_HUMAN

NCBI Description

PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008]

Uniprot Description

PEAR1: When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells. Belongs to the MEGF family.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.1

Cellular Component: integral to membrane; phagocytic cup

Biological Process: recognition of apoptotic cell