Rabbit anti-Human PDZD3 Polyclonal Antibody | anti-PDZD3 antibody

PDZD3 Antibody, HRP conjugated

Cat. Num. AAA7050628

• Gene Names: PDZD3; IKEPP; PDZK2; NHERF4
• Reactivity: Human
• Applications: ELISA
• Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
• Synonyms: PDZD3; Polyclonal Antibody; PDZD3 Antibody; HRP conjugated; Na(+)/H(+) exchange regulatory cofactor NHE-RF4; NHERF-4; Intestinal and kidney-enriched PDZ protein; Natrium-phosphate cotransporter IIa C-terminal-associated protein 2; Na/Pi cotransporter C-terminal-associated protein 2; NaPi-Cap2; PDZ domain-containing protein 2; PDZ domain-containing protein 3; Sodium-hydrogen exchanger regulatory factor 4; IKEPP; NHERF4; PDZK2; DLNB27; anti-PDZD3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
• Form/Format: Liquid
• Sequence Length: 505

• Applicable Applications for anti-PDZD3 antibody: ELISA (EIA)
• Immunogen: Recombinant human Na(+)/H(+) exchange regulatory cofactor NHE-RF4 protein (42-291AA)
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugation: HRP
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-82687 / sc-82689
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-PDZD3 antibody

Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions.

References

[1]"Complete sequencing and characterization of 21, 243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36: 40-45(2004). [2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. Sakaki Y. Nature 440: 497-500(2006). [3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project TeamGenome Res. 14: 2121-2127(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 270483764
• NCBI GeneID: 79849
• NCBI Accession #: NP_001161940.1
• NCBI GenBank Nucleotide #: NM_001168468.1
• UniProt Accession #: Q86UT5; Q8N6R4; Q8NAW7; Q8NEX7; Q9H5Z3
• Molecular Weight: 24,105 Da
• NCBI Official Full Name: Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform 1
• NCBI Official Synonym Full Names: PDZ domain containing 3
• NCBI Official Symbol: PDZD3
• NCBI Official Synonym Symbols: IKEPP; PDZK2; NHERF4
• NCBI Protein Information: Na(+)/H(+) exchange regulatory cofactor NHE-RF4
• UniProt Protein Name: Na(+)/H(+) exchange regulatory cofactor NHE-RF4
• Protein Family: Na(+)/H(+) exchange regulatory cofactor
• UniProt Gene Name: PDZD3
• UniProt Synonym Gene Names: IKEPP; NHERF4; PDZK2; NHERF-4; Na/Pi cotransporter C-terminal-associated protein 2; NaPi-Cap2
• UniProt Entry Name: NHRF4_HUMAN

NCBI Description

Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008]

Uniprot Description

PDZD3: Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: apical part of cell; brush border; cytosol; subapical complex

Molecular Function: guanylate cyclase inhibitor activity; ion channel inhibitor activity; protein binding; protein C-terminus binding

Biological Process: negative regulation of cGMP biosynthetic process; receptor guanylyl cyclase signaling pathway; response to toxin