Rabbit anti-Human PDXK Polyclonal Antibody | anti-PDXK antibody

PDXK antibody

Cat. Num. AAA9408247

• Gene Names: PDXK; PKH; PNK; PRED79; C21orf97; HEL-S-1a; C21orf124
• Reactivity: Human
• Applications: Western Blot, Immunofluorescence
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: PDXK; Polyclonal Antibody; PDXK antibody; PKH; PNK; PRED79; C21orf97; HEL-S-1a; C21orf124; anti-PDXK antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total PDXK antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 312

• Applicable Applications for anti-PDXK antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: Western blotting: 1:500 - 1:2000; Immunofluorescence: 1:50 - 1:200
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human PDXK.
• Target Name: PDXK
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using PDXK antibody.)

Immunofluorescence (IF)

(Immunofluorescence analysis of U2OS cell using PDXK antibody. Blue: DAPI for nuclear staining.)

Related Product Information for anti-PDXK antibody

The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Product Categories/Family for anti-PDXK antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4505701
• NCBI GeneID: 8566
• NCBI Accession #: NP_003672.1
• NCBI GenBank Nucleotide #: NM_003681.4
• UniProt Accession #: O00764; Q7Z2Y0; Q9BS02
• Molecular Weight: 26,827 Da
• NCBI Official Full Name: pyridoxal kinase
• NCBI Official Synonym Full Names: pyridoxal (pyridoxine, vitamin B6) kinase
• NCBI Official Symbol: PDXK
• NCBI Official Synonym Symbols: PKH; PNK; PRED79; C21orf97; HEL-S-1a; C21orf124
• NCBI Protein Information: pyridoxal kinase
• UniProt Protein Name: Pyridoxal kinase
• Protein Family: Pyridoxine kinase
• UniProt Gene Name: PDXK
• UniProt Synonym Gene Names: C21orf124; C21orf97; PKH; PNK
• UniProt Entry Name: PDXK_HUMAN

NCBI Description

The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

PDXK: Required for synthesis of pyridoxal-5-phosphate from vitamin B6. Belongs to the pyridoxine kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cofactor and Vitamin Metabolism - vitamin B6; Kinase, other; EC 2.7.1.35

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: potassium ion binding; sodium ion binding; protein homodimerization activity; zinc ion binding; pyridoxal kinase activity; magnesium ion binding; lithium ion binding; ATP binding; pyridoxal phosphate binding

Biological Process: cell proliferation; vitamin metabolic process; vitamin B6 metabolic process; pyridoxal 5'-phosphate salvage; phosphorylation; water-soluble vitamin metabolic process; pyridoxal phosphate biosynthetic process