Rabbit PDL-2 Polyclonal Antibody | anti-PDCD1LG2 antibody

PDL-2 Antibody

Cat. Num. AAA151188

• Gene Names: PDCD1LG2; B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: PDL-2 Antibody is affinity chromatography purified via peptide column.
• Synonyms: PDL-2; Polyclonal Antibody; PDL-2 Antibody; B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2; Programmed cell death 1 ligand 2; Butyrophilin B7-DC; PD-1 ligand 2; programmed cell death 1 ligand 2; anti-PDCD1LG2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: PDL-2 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 273

• Applicable Applications for anti-PDCD1LG2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: PDL-2 antibody can be used for detection of PDL-2 by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: PDL-2 antibody was raised against a 16 amino acid synthetic peptide from near the center of human PDL-2.
• Buffer: PDL-2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: PDL-2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of PD-L2 in Raji cell lysate with PD-L2 antibody at 0.5 and 1 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of PD-L2 in mouse brain tissue with PD-L2 antibody at 2.5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of PD-L2 in Mouse Brain cells with PD-L2 antibody at 20 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of PD-L2 in mouse brain tissue with PD-L2 antibody at 2.5 μg/ml.)

Immunofluorescence (IF)

(Immunofluorescence of PD-L2 in mouse brain tissue with PD-L2 antibody at 20 μg/ml.)

Immunofluorescence (IF)

(Immunofluorescence of PD-L2 in mouse brain tissue with PD-L2 antibody at 20 μg/ml.Green: PD-L2 Antibody (4063)Blue: DAPI staining)

Related Product Information for anti-PDCD1LG2 antibody

PDL-2 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by co gnate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PDL-2 can act to stimulate an immunogenic response through and alternative receptor from PD-1.

NCBI and Uniprot Product Information

• NCBI GI #: 190014605
• NCBI GeneID: 80380
• NCBI Accession #: NP_079515
• NCBI GenBank Nucleotide #: NM_025239.3
• UniProt Accession #: Q9BQ51; Q14CN8; Q5T7Z6; Q6JXL8; Q6JXL9
• Molecular Weight: Predicted: 30 kDa; ; Observed: 32 kDa
• NCBI Official Full Name: programmed cell death 1 ligand 2
• NCBI Official Synonym Full Names: programmed cell death 1 ligand 2
• NCBI Official Symbol: PDCD1LG2
• NCBI Official Synonym Symbols: B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2
• NCBI Protein Information: programmed cell death 1 ligand 2; B7-DC; PD-1 ligand 2; PD-1-ligand 2; PDCD1 ligand 2; butyrophilin B7-DC; programmed death ligand 2; B7 dendritic cell molecule
• UniProt Protein Name: Programmed cell death 1 ligand 2
• Protein Family: Programmed cell death
• UniProt Gene Name: PDCD1LG2
• UniProt Synonym Gene Names: B7DC; CD273; PDCD1L2; PDL2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; Programmed death ligand 2; B7-DC
• UniProt Entry Name: PD1L2_HUMAN

Uniprot Description

PDCD1LG2: Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 9p24.2

Cellular Component: plasma membrane; integral to membrane; endomembrane system

Biological Process: negative regulation of interleukin-10 production; negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; T cell costimulation; immune response; positive regulation of T cell proliferation