Rabbit PDE7A Polyclonal Antibody | anti-PDE7A antibody

Rabbit Polyclonal to Human PDE7A

Cat. Num. AAA240106

• Gene Names: PDE7A; HCP1; PDE7
• Reactivity: Bat, Gibbon, Bovine, Dog, Xenopus, Gorilla, Human, Monkey, Orangutan, Rabbit; Predicted Reactivity: Mouse, Rat, Hamster (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: PDE7A; Polyclonal Antibody; Rabbit Polyclonal to Human PDE7A; Anti-PDE7A Antibody (N-Terminus) IHC-plus; PDE7A1; PDE7A2; Phosphodiesterase 7A; Phosphodiesterase isozyme 7; PDE7; HCP1; TM22; Human PDE7A; anti-PDE7A antibody

• Host: Rabbit
• Reactivity: Bat, Gibbon, Bovine, Dog, Xenopus, Gorilla, Human, Monkey, Orangutan, Rabbit; Predicted Reactivity: Mouse, Rat, Hamster (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human PDE7A. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 0.4 mg/ml (varies by lot)
• Sequence Length: 482

• Applicable Applications for anti-PDE7A antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (20 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
• Target Species: Human
• Immunogen Description: Synthetic 17 amino acid peptide from N-terminus of human PDE7A. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Bovine, Dog, Bat, Elephant, Panda, Rabbit, Opossum, Xenopus (100%).
• Immunogen Type: Synthetic peptide
• Immunogen: PDE7A antibody was raised against synthetic 17 amino acid peptide from N-terminus of human PDE7A. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Bovine, Dog, Bat, Elephant, Panda, Rabbit, Opossum, Xenopus (100%); Mouse, Rat, Hamster, Turkey, Lizard (94%); Zebrafish (82%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-PDE7A antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-PDE7A antibody

Phosphodiesterase 7A, a cAMP-specific phosphodiesterase, has been shown to affect memory, T-cell functioning and emesis and has been implicated in depression. Two isoforms (PDE7A1 and PDE7A2) which differ at their N-terminal region, have been reported.

Product Categories/Family for anti-PDE7A antibody

Family: Phosphodiesterase; Subfamily: PDE - cAMP-specific

NCBI and Uniprot Product Information

• NCBI GI #: 334085277
• NCBI GeneID: 5150
• NCBI Accession #: NP_001229247.1
• NCBI GenBank Nucleotide #: NM_001242318.2
• UniProt Accession #: Q13946; O15380; Q96T72; A0AVH6; A8K436; A8K9G5
• Molecular Weight: 48,828 Da
• NCBI Official Full Name: high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform c
• NCBI Official Synonym Full Names: phosphodiesterase 7A
• NCBI Official Symbol: PDE7A
• NCBI Official Synonym Symbols: HCP1; PDE7
• NCBI Protein Information: high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A; TM22; phosphodiesterase isozyme 7
• UniProt Protein Name: High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
• Protein Family: High affinity cAMP-specific 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE7A
• UniProt Entry Name: PDE7A_HUMAN

NCBI Description

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]

Uniprot Description

PDE7A: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - purine; EC 3.1.4.53; Phosphodiesterase

Chromosomal Location of Human Ortholog: 8q13

Cellular Component: cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; metal ion binding

Biological Process: cAMP catabolic process; signal transduction