Rabbit PDE6 Alpha Polyclonal Antibody | anti-PDE6 antibody

Pan PDE6 Alpha Antibody FITC-Conjugated

Cat. Num. AAA543554

• Gene Names: PDE6C; COD4; ACHM5; PDEA2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
• Synonyms: PDE6 Alpha; Polyclonal Antibody; Pan PDE6 Alpha Antibody FITC-Conjugated; 5''-cyclic phosphodiesterase subunit alpha; CGPR A; GMP PDE alpha; PDE 6 alpha; PDE V B1; PDEA; Phosphodiesterase 6 alpha; Retinal Rod Photoreceptor cGMP; Rod cGMP specific 3' 5' cyclic phosphodiesterase alpha subunit antibody; anti-PDE6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Form/Format: FITC-Conjugated
• Concentration: 0.50-0.75 ug/ul in antibody stabilization buffer (varies by lot)
• Sequence Length: 858

• Applicable Applications for anti-PDE6 antibody: Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: Confocal Microscopy||1:250; Dot Blot: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:250; Immunofluorescence: 1:250; Immunohistochemistry: 1:250; Immunoprecipitation: 1:250; Western Blot: 1:500
• Immunogen: Synthetic cyclic peptide common to all PDE6 alpha variants.
• Molecular Function: Hydrolase, 3', 5'-cyclic-GMP phosphodiesterase activity, cGMP binding
• Structure: Composed of two alpha' subunits that are associated with 3 smaller proteins of 11, 13, and 15 kDa.
• Subcellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side
• Preparation and Storage: -20 degree C for long term storage

Related Product Information for anti-PDE6 antibody

FITC-Conjugated Cone cGMP-specific 3', 5'-cyclic phosphodiesterase subunit alpha Antibody

NCBI and Uniprot Product Information

• NCBI GI #: 90111861
• NCBI GeneID: 5146
• UniProt Accession #: P51160; Q5VY29; A6NCR6
• Molecular Weight: 99,147 Da
• NCBI Official Full Name: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
• NCBI Official Synonym Full Names: phosphodiesterase 6C
• NCBI Official Symbol: PDE6C
• NCBI Official Synonym Symbols: COD4; ACHM5; PDEA2
• NCBI Protein Information: cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
• UniProt Protein Name: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
• Protein Family: cGMP-specific 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE6C
• UniProt Synonym Gene Names: PDEA2
• UniProt Entry Name: PDE6C_HUMAN

NCBI Description

This gene encodes the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa. Mutations in this gene are associated with cone dystrophy type 4 (COD4). [provided by RefSeq, Mar 2010]

Uniprot Description

PDE6C: Defects in PDE6C are the cause of cone dystrophy type 4 (COD4). An early-onset cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies in which some loss of peripheral vision also occurs. Belongs to the cyclic nucleotide phosphodiesterase family.

Protein type: EC 3.1.4.35; Phosphodiesterase

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: plasma membrane

Molecular Function: 3',5'-cyclic-GMP phosphodiesterase activity; cGMP binding; metal ion binding

Biological Process: metabolic process; phototransduction, visible light; retinal cone cell development; visual perception

Disease: Cone Dystrophy 4