Rabbit PDE4B/C/D Polyclonal Antibody | anti-PDE4B/C/D antibody

PDE4B/C/D (Phospho Ser133/119/190) Polyclonal Antibody

Cat. Num. AAA9458796

• Gene Names: PDE4B; DPDE4; PDEIVB
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: PDE4B/C/D; Polyclonal Antibody; PDE4B/C/D (Phospho Ser133/119/190) Polyclonal Antibody; PDE4B; DPDE4; cAMP-specific 3'; 5'-cyclic phosphodiesterase 4B; PDE32; PDE4C; DPDE1; 5'-cyclic phosphodiesterase 4C; PDE21; PDE4D; DPDE3; 5'-cyclic phosphodiesterase 4D; PDE43; anti-PDE4B/C/D antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Phospho-PDE4B/C/D (S133/119/190) Polyclonal Antibody detects endogenous levels of PDE4B/C/D protein only when phosphorylated at S133/119/190.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-PDE4B/C/D antibody: Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), Immunofluorescence (IF)(paraffin, section), ELISA (EIA)
• Application Notes: WB: 1/500-1/2000; IHC: 1/100-1/300; ELISA: 1/20000
• Immunogen: The antiserum was produced against synthesized peptide derived from human PDE4D around the phosphorylation site of Ser190/53. AA range:156-205
• Preparation and Storage: Store at -20 degree C for 1 year

Related Product Information for anti-PDE4B/C/D antibody

phosphodiesterase 4B (PDE4B), Homo sapiens. This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Product Categories/Family for anti-PDE4B/C/D antibody

Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 32171241
• NCBI GeneID: 5142
• NCBI Accession #: NP_002591.2
• NCBI GenBank Nucleotide #: NM_002600.3
• UniProt Accession #: Q07343; Q08493; Q08499
• Molecular Weight: 57,709 Da
• NCBI Official Full Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 1
• NCBI Official Synonym Full Names: phosphodiesterase 4B, cAMP-specific
• NCBI Official Symbol: PDE4B
• NCBI Official Synonym Symbols: DPDE4; PDEIVB
• NCBI Protein Information: cAMP-specific 3',5'-cyclic phosphodiesterase 4B; dunce-like phosphodiesterase E4; phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
• UniProt Protein Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4B
• UniProt Gene Name: PDE4B
• UniProt Synonym Gene Names: DPDE4
• UniProt Entry Name: PDE4B_HUMAN

NCBI Description

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Uniprot Description

PDE4B: a cAMP-specific phosphodiesterase. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. Inhibited by rolipram. Three alternatively-spliced isoforms have been described.

Protein type: Phosphodiesterase; EC 3.1.4.53; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 1p31

Cellular Component: perinuclear region of cytoplasm; voltage-gated calcium channel complex; cytosol; nucleus; Z disc

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; metal ion binding; cAMP binding; 3',5'-cyclic-nucleotide phosphodiesterase activity

Biological Process: neutrophil chemotaxis; positive regulation of interferon-gamma production; cAMP catabolic process; positive regulation of interleukin-2 production; neutrophil homeostasis; T cell receptor signaling pathway; leukocyte migration