Rabbit PDE4B Polyclonal Antibody | anti-PDE4B antibody

Pan PDE4B Antibody BIOTIN-Conjugated

Cat. Num. AAA543493

• Gene Names: PDE4B; DPDE4; PDEIVB
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
• Synonyms: PDE4B; Polyclonal Antibody; Pan PDE4B Antibody BIOTIN-Conjugated; 5''-cyclic phosphodiesterase 4B; cAMP-specific 3''; cAMP-specific 3'; 5'-cyclic phosphodiesterase 4B; DPDE4; dunce-like phosphodiesterase E4; MGC126529; PDE 4B; PDE IVB; PDE32; PDE4B5; PDEIVB; Phosphodiesterase 4B; Phosphodiesterase-4B cAMP-specific (dunce (Drosophila)-homolog) antibody; anti-PDE4B antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: This antibody detects all PDE4B proteins, including PDE4B1, PDE4B2, PDE4B3, and a 66 kDa PDE4B variant. It does not cross-react with other PDE family members such as PDE4A, PDE4C, or PDE4D.
• Form/Format: BIOTIN-Conjugated
• Concentration: 0.68 ug/ul in antibody stabilization buffer (varies by lot)
• Sequence Length: 736

• Applicable Applications for anti-PDE4B antibody: Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: Confocal Microscopy||1:250; Dot Blot: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:250; Immunofluorescence: 1:250; Immunohistochemistry: 1:250; Immunoprecipitation: 1:350; Western Blot: 1:500-1:1,000
• Immunogen: Synthetic peptide common to all PDE4B subtypes taken near C-terminal
• Expression: Expressed in brain, heart, lung and skeletal muscle.
• Determinant: C-epitope
• Molecular Function: Hydrolase, 3', 5'-cyclic-AMP phosphodiesterase activity, cAMP binding
• Preparation and Storage: -20 degree C for long term storage

Related Product Information for anti-PDE4B antibody

BIOTIN-Conjugated cAMP-specific 3', 5'-cyclic phosphodiesterase 4B Antibody C-epitope
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory

NCBI and Uniprot Product Information

• NCBI GI #: 729163
• NCBI GeneID: 5142
• UniProt Accession #: Q07343; O15443; Q13945; Q5TEK4; Q5TEK5; Q5TEK6; A5YW33
• Molecular Weight: 57,709 Da
• NCBI Official Full Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4B
• NCBI Official Synonym Full Names: phosphodiesterase 4B
• NCBI Official Symbol: PDE4B
• NCBI Official Synonym Symbols: DPDE4; PDEIVB
• NCBI Protein Information: cAMP-specific 3',5'-cyclic phosphodiesterase 4B
• UniProt Protein Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4B
• Protein Family: cAMP-specific 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE4B
• UniProt Synonym Gene Names: DPDE4
• UniProt Entry Name: PDE4B_HUMAN

NCBI Description

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Uniprot Description

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.