Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using PDCD10 antibody.)
Rabbit anti-Human, Mouse PDCD10 Polyclonal Antibody | anti-PDCD10 antibody
PDCD10 Polyclonal Antibody
IF: 1:50-1:200
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using PDCD10 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using PDCD10 antibody.)
Western Blot (WB)
(Western blot analysis of extracts from normal (control) and PDCD10 knockout (KO) HeLa cells, using PDCD10 antibody.)
Western Blot (WB)
(Western blot analysis of extracts from normal (control) and PDCD10 knockout (KO) HeLa cells, using PDCD10 antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
PDCD10: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development. Defects in PDCD10 are the cause of cerebral cavernous malformations type 3 (CCM3). Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and usually present clinically during the 3rd to 5th decade of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters. Belongs to the PDCD10 family.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 3q26.1
Cellular Component: Golgi membrane; Golgi apparatus; cytoplasm; plasma membrane; cytosol
Molecular Function: protein binding; protein homodimerization activity; protein N-terminus binding; protein kinase binding
Biological Process: protein stabilization; positive regulation of peptidyl-serine phosphorylation; positive regulation of stress-activated MAPK cascade; positive regulation of MAP kinase activity; response to hydrogen peroxide; establishment of Golgi localization; positive regulation of cell proliferation; stress fiber formation; regulation of Rho protein signal transduction; angiogenesis; positive regulation of Notch signaling pathway; negative regulation of apoptosis; positive regulation of cell migration
Disease: Cerebral Cavernous Malformations 3
Research Articles on PDCD10
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Product Notes
The PDCD10 pdcd10 (Catalog #AAA9432543) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PDCD10 Polyclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PDCD10 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). WB: 1:200-1:2000 IF: 1:50-1:200. Researchers should empirically determine the suitability of the PDCD10 pdcd10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PDCD10, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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