Western Blot (WB)
(PCSK7 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PCSK7 antibody detected the PCSK7 protein (arrow).)
Rabbit anti-Human PCSK7 Polyclonal Antibody | anti-PCSK7 antibody
PCSK7 Antibody (C-term)
Western Blot (WB)
(PCSK7 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PCSK7 antibody detected the PCSK7 protein (arrow).)
Western Blot (WB)
(PCSK7 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PCSK7 antibody detected the PCSK7 protein (arrow).)
subtilisin-like proprotein convertase family. The members of this
family are proprotein convertases that process latent precursor
proteins into their biologically active products. This encoded
protein is a calcium-dependent serine endoprotease. It is
structurally related to its family members, PACE and PACE4. This
protein is concentrated in the trans-Golgi network, associated with
the membranes, and is not secreted. It can process proalbumin and
is thought to be responsible for the activation of HIV envelope
glycoproteins gp160 and gp140. This gene has been implicated in the
transcriptional regulation of housekeeping genes. Multiple
alternatively spliced transcripts are described for this gene but
their full length nature is not yet known. Downstream of this
gene's map location at 11q23-q24, nucleotides that match part of
this gene's 3' end are duplicated and inverted. A translocation
breakpoint associated with lymphoma occurs between this gene and
its inverted counterpart.
McColl, B.K., et al. FASEB J. 21(4):1088-1098(2007)
Bruzzaniti, A., et al. Peptides 23(5):863-875(2002)
Fugere, M., et al. J. Biol. Chem. 277(10):7648-7656(2002)
Pearton, D.J., et al. Exp. Dermatol. 10(3):193-203(2001)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014]
Uniprot Description
PCSK7: Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif. Belongs to the peptidase S8 family.
Protein type: Membrane protein, integral; Protease; EC 3.4.21.-
Chromosomal Location of Human Ortholog: 11q23-q24
Cellular Component: integral to Golgi membrane
Molecular Function: peptidase activity; serine-type endopeptidase activity
Biological Process: peptide hormone processing; protein processing; proteolysis
Research Articles on PCSK7
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Product Notes
The PCSK7 pcsk7 (Catalog #AAA9206294) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 692-721. The PCSK7 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PCSK7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the PCSK7 pcsk7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PCSK7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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