Western Blot (WB)
(Western Blot analysis of various samples using Proliferating Cell Nuclear Antigen Polyclonal Antibody at dilution of 1:2000.)
Rabbit PCNA Polyclonal Antibody | anti-PCNA antibody
PCNA Polyclonal Antibody
IHC: 1:300-1:1000
IF: 1:200-1:500
Western Blot (WB)
(Western Blot analysis of various samples using Proliferating Cell Nuclear Antigen Polyclonal Antibody at dilution of 1:2000.)
Western Blot (WB)
(Western Blot analysis of various samples using Proliferating Cell Nuclear Antigen Polyclonal Antibody at dilution of 1:2000.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded Human tonsil using Proliferating Cell Nuclear Antigen Polyclonal Antibody at dilution of 1:300.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded Human tonsil using Proliferating Cell Nuclear Antigen Polyclonal Antibody at dilution of 1:300.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded Mouse lung using Proliferating Cell Nuclear Antigen Polyclonal Antibody at dilution of 1:300.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded Mouse lung using Proliferating Cell Nuclear Antigen Polyclonal Antibody at dilution of 1:300.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded Rat spleen using Proliferating Cell Nuclear Antigen Polyclonal Antibody at dilution of 1:300.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded Rat spleen using Proliferating Cell Nuclear Antigen Polyclonal Antibody at dilution of 1:300.)
Immunofluorescence (IF)
(Immunofluorescence analysis of Mouse lung cancer using Proliferating Cell Nuclear Antigen Polyclonal Antibody at dilution of 1:200.)
Immunofluorescence (IF)
(Immunofluorescence analysis of Mouse lung cancer using Proliferating Cell Nuclear Antigen Polyclonal Antibody at dilution of 1:200.)
NCBI and Uniprot Product Information
Observed: 33kDa
NCBI Description
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
Uniprot Description
Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
Research Articles on PCNA
Similar Products
Product Notes
The PCNA pcna (Catalog #AAA2556028) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PCNA Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PCNA can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). WB: 1:2000 IHC: 1:300-1:1000 IF: 1:200-1:500. Researchers should empirically determine the suitability of the PCNA pcna for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PCNA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
