Rabbit anti-Human PCID2 Polyclonal Antibody | anti-PCID2 antibody

PCID2 Antibody

Cat. Num. AAA7052897

• Gene Names: PCID2; F10
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, Immunofluorescence
• Purity: >95%, Protein G purified
• Synonyms: PCID2; Polyclonal Antibody; PCID2 Antibody; PCI domain-containing protein 2; CSN12-like protein; HT004; anti-PCID2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 399

• Applicable Applications for anti-PCID2 antibody: ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: IHC: 1:20-1:200; IF: 1:50-1:200
• Immunogen: Recombinant Human PCI domain-containing protein 2 protein (2-250AA)
• Conjugation: Non-conjugated
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using MBS7052897 at dilution of 1:100)

Immunofluorescence (IF)

(Immunofluorescent analysis of Hela cells using MBS7052897 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

Related Product Information for anti-PCID2 antibody

Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.

NCBI and Uniprot Product Information

• NCBI GI #: 224451001
• NCBI GeneID: 55795
• NCBI Accession #: NP_001120674.1
• NCBI GenBank Nucleotide #: NM_001127202.3
• UniProt Accession #: Q5JVF3; Q3ZCX1; Q5TC57; Q5TC58; Q9H7K1; Q9HBZ7; Q9NUK6; Q9NVY1; Q9NW44; Q9NWH3; A6NK09
• Molecular Weight: 52,100 Da
• NCBI Official Full Name: PCI domain-containing protein 2 isoform 1
• NCBI Official Synonym Full Names: PCI domain containing 2
• NCBI Official Symbol: PCID2
• NCBI Official Synonym Symbols: F10
• NCBI Protein Information: PCI domain-containing protein 2
• UniProt Protein Name: PCI domain-containing protein 2
• Protein Family: PCI domain-containing protein
• UniProt Gene Name: PCID2

NCBI Description

This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoint protein. This protein also interacts with and stabilizes Brca2 (breast cancer 2) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Uniprot Description

PCID2: a protein of unknown function.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: nuclear pore

Molecular Function: double-stranded DNA binding; protein binding; RNA binding

Biological Process: negative regulation of apoptosis; poly(A)+ mRNA export from nucleus; positive regulation of transcription, DNA-dependent; regulation of mRNA stability; RNA elongation from RNA polymerase II promoter; spleen development