Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human colon tissue slide using MBS767974 (CLCA2 Antibody) at dilution of 1:50)
Rabbit anti-Human, Mouse CLCA2 Polyclonal Antibody | anti-CLCA2 antibody
CLCA2 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human colon tissue slide using MBS767974 (CLCA2 Antibody) at dilution of 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human colon tissue slide using MBS767974 (CLCA2 Antibody) at dilution of 1:50)
Western Blot (WB)
(mouse lung tissue were subjected to SDS PAGE followed by western blot with MBS767974 (CLCA2 antibody) at dilution of 1:300)
Western Blot (WB)
(mouse lung tissue were subjected to SDS PAGE followed by western blot with MBS767974 (CLCA2 antibody) at dilution of 1:300)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer. [provided by RefSeq, Jul 2008]
Uniprot Description
CLCA5: Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. Belongs to the CLCR family.
Protein type: Membrane protein, integral; Channel, chloride
Chromosomal Location of Human Ortholog: 1p22.3
Cellular Component: basal plasma membrane; cell junction; extracellular region; integral to plasma membrane; nucleus; plasma membrane
Molecular Function: chloride channel activity; intracellular calcium activated chloride channel activity; ligand-gated ion channel activity; metal ion binding; metalloendopeptidase activity
Biological Process: cell adhesion; proteolysis; transport
Research Articles on CLCA2
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Product Notes
The CLCA2 clca2 (Catalog #AAA767974) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CLCA2 Rabbit Polyclonal reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CLCA2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the CLCA2 clca2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CLCA2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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