Rabbit anti-Human PCDHGB4 Polyclonal Antibody | anti-PCDHGB4 antibody

PCDHGB4, ID (PCDHGB4, CDH20, FIB2, Protocadherin gamma-B4, Cadherin-20, Fibroblast cadherin-2) (APC)

Cat. Num. AAA6331716

• Gene Names: PCDHGB4; FIB2; CDH20; PCDH-GAMMA-B4
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PCDHGB4; Polyclonal Antibody; ID (PCDHGB4; CDH20; FIB2; Protocadherin gamma-B4; Cadherin-20; Fibroblast cadherin-2) (APC); Fibroblast cadherin-2; anti-PCDHGB4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-PCDHGB4 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: PCDHGB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic between 352-379 amino acids selected from the Central region of human PCDHGB4.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(PCDHGB4 Antibody (Center) western blot analysis in Uterus tissue lysates (35ug/lane).This demonstrates the PCDHGB4 antibody detected the PCDHGB4 protein (arrow).)

Related Product Information for anti-PCDHGB4 antibody

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. This particular family member is expressed in fibroblasts and is thought to play a role in wound healing in response to injury. Alternative splicing has been described for the gamma cluster genes.

Product Categories/Family for anti-PCDHGB4 antibody

Antibodies; Cadherin

References

Wu, Q., et al. Genome Res. 11(3):389-404(2001). Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000). Yagi, T., et al. Genes Dev. 14(10):1169-1180(2000). Wu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 97(7):3124-3129(2000). Wu, Q., et al. Cell 97(6):779-790(1999).

NCBI and Uniprot Product Information

• NCBI GI #: 13470082
• NCBI GeneID: 8641
• NCBI Accession #: NP_003727.1
• NCBI GenBank Nucleotide #: NM_003736.2
• UniProt Accession #: Q9UN71; O15099; Q2M267; Q9UN64
• Molecular Weight: 87,447 Da
• NCBI Official Full Name: protocadherin gamma-B4 isoform 1
• NCBI Official Synonym Full Names: protocadherin gamma subfamily B, 4
• NCBI Official Symbol: PCDHGB4
• NCBI Official Synonym Symbols: FIB2; CDH20; PCDH-GAMMA-B4
• NCBI Protein Information: protocadherin gamma-B4
• UniProt Protein Name: Protocadherin gamma-B4
• Protein Family: Protocadherin
• UniProt Gene Name: PCDHGB4
• UniProt Synonym Gene Names: CDH20; FIB2; PCDH-gamma-B4
• UniProt Entry Name: PCDGG_HUMAN

NCBI Description

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. This particular family member is expressed in fibroblasts and is thought to play a role in wound healing in response to injury. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]