Rabbit anti-Human PCDHB12 Polyclonal Antibody | anti-PCDHB12 antibody

PCDHB12, CT (PCDHB12, Protocadherin beta-12)

Cat. Num. AAA6005509

• Gene Names: PCDHB12; PCDH-BETA12
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: PCDHB12; Polyclonal Antibody; CT (PCDHB12; Protocadherin beta-12); Anti -PCDHB12; anti-PCDHB12 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-PCDHB12 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot, Immunohistochemistry, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500; Immunohistochemistry: 1:10-50
• Immunogen: PCDHB12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 765-795 amino acids from the C-terminal region of human PCDHB12.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(PCDHB12 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PCDHB12 antibody detected the PCDHB12 protein (arrow).)

Immunohistochemistry (IHC)

(PCDHB12 Antibdy (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PCDHB12 Antibdy (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-PCDHB12 antibody

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.

Product Categories/Family for anti-PCDHB12 antibody

Antibodies; Abs to Cadherin

NCBI and Uniprot Product Information

• NCBI GI #: 9256606
• NCBI GeneID: 56124
• NCBI Accession #: NP_061755.1
• NCBI GenBank Nucleotide #: NM_018932.3
• UniProt Accession #: Q9Y5F1
• Molecular Weight: 86,770 Da
• NCBI Official Full Name: protocadherin beta-12
• NCBI Official Synonym Full Names: protocadherin beta 12
• NCBI Official Symbol: PCDHB12
• NCBI Official Synonym Symbols: PCDH-BETA12
• NCBI Protein Information: protocadherin beta-12; PCDH-beta-12
• UniProt Protein Name: Protocadherin beta-12
• Protein Family: Protocadherin
• UniProt Gene Name: PCDHB12
• UniProt Synonym Gene Names: PCDH-beta-12
• UniProt Entry Name: PCDBC_HUMAN

NCBI Description

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]

Uniprot Description

PCDHB12: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: integral to plasma membrane

Molecular Function: calcium ion binding

Biological Process: nervous system development; cell adhesion; homophilic cell adhesion