Rabbit anti-Human PCBP4/MCG10 Polyclonal Antibody | anti-PCBP4 antibody

Anti-PCBP4/MCG10 Antibody, Rabbit Polyclonal

Cat. Num. AAA8110434

• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: PCBP4/MCG10; Polyclonal Antibody; Anti-PCBP4/MCG10 Antibody; Rabbit Polyclonal; PCBP4/MCG10 Antibody; Rabbit PAb; Antigen Affinity Purified; poly(rC) binding protein 4; Anti-CBP Antibody; Anti-LIP4 Antibody; Anti-MCG10 Antibody; anti-PCBP4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human PCBP4/MCG10
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-PCBP4 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:200-1:1000
• Immunogen: E Coli-derived Human PCBP4/MCG10 fragment
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with E Coli-derived Human PCBP4/MCG10 fragment, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human PCBP4 in human kidney with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)

Immunohistochemistry (IHC)

(Immunochemical staining of human PCBP4 in human brain with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-PCBP4 antibody

Poly(C)-binding protein 4 (PCBP4), also known as MCG10, is an RBP belonging to the poly(C)-binding protein family and a target of p53 tumor suppressor. PCBP4 plays a role in the cell cycle and is implicated in lung tumor suppression. Ectopic expression of PCBP4 induces cell-cycle arrest in G2 and apoptosis. PCBP4 regulates both basal and stress-induced p21 expression through binding p21 3'-UTR and modulating p21 mRNA stability. alpha CP-4 is an RNA-binding protein coded by PCBP4, a gene mapped to 3p21, a commonly deleted region in lung cancer. PCBP4 plays important role in the induction of cisplatin resistance in human maxillary cancers. PCBP4 is a novel molecular target for the therapy of head and neck cancers, especially cisplatin-resistant cancers.

References

Yan W, et al. (2016) Mice deficient in poly(c)-binding protein 4 are susceptible to spontaneous tumors through increased expression of zfp871 that targets p53 for degradation. Genes Dev 30 (5): 522-534.Scoumanne A, et al. (2011) The cyclin-dependent kinase inhibitor p21 is regulated by rna-binding protein pcbp4 via mrna stability. Nucleic Acids Res 39 (1): 213-224.Pio R, et al. (2004) Alpha cp-4, encoded by a putative tumor suppressor gene at 3p21, but not its alternative splice variant alpha cp-4a, is underexpressed in lung cancer. Cancer Res 64 (12): 4171-4179.Ito Y, et al. (2015) Suppression of poly(rc)-binding protein 4 (pcbp4) reduced cisplatin resistance in human maxillary cancer cells. Sci Rep 5 12360.