Rabbit anti-Human PBXIP1 Polyclonal Antibody | anti-PBXIP1 antibody

PBXIP1 Rabbit Polyclonal

Cat. Num. AAA7602418

• Gene Names: PBXIP1; HPIP
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: PBXIP1; Polyclonal Antibody; PBXIP1 Rabbit Polyclonal; anti-PBXIP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 731

• Applicable Applications for anti-PBXIP1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
• Immunogen: Pre-B-cell leukemia homeobox interacting protein 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human lung cancer using MBS7602418 (PBXIP1 antibody) at dilution of 1:100)

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7602418 (PBXIP1 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 19923830
• NCBI GeneID: 57326
• NCBI Accession #: NP_065385.2
• NCBI GenBank Nucleotide #: NM_020524.3
• Molecular Weight: 72,920 Da
• NCBI Official Full Name: pre-B-cell leukemia transcription factor-interacting protein 1 isoform 1
• NCBI Official Synonym Full Names: PBX homeobox interacting protein 1
• NCBI Official Symbol: PBXIP1
• NCBI Official Synonym Symbols: HPIP
• NCBI Protein Information: pre-B-cell leukemia transcription factor-interacting protein 1
• UniProt Protein Name: Pre-B-cell leukemia transcription factor-interacting protein 1
• Protein Family: Pre-B-cell leukemia transcription factor-interacting protein
• UniProt Gene Name: PBXIP1
• UniProt Synonym Gene Names: HPIP
• UniProt Entry Name: PBIP1_HUMAN

NCBI Description

The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015]

Uniprot Description

PBXIP1: Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: cytosol; microtubule; nucleus

Molecular Function: protein binding; transcription corepressor activity

Biological Process: cell differentiation; multicellular organismal development; negative regulation of transcription, DNA-dependent