Rabbit anti-Mouse Paxenopus 6 Polyclonal Antibody | anti-Pax6 antibody

Paxenopus 6 (Paired Boxenopus Protein Paxenopus-6, Oculorhombin, Paxenopus 6, Paxenopus-6, Sey) (APC)

Cat. Num. AAA6458022

• Gene Names: Pax6; Dey; Sey; AEY11; Pax-6; Gsfaey11; 1500038E17Rik
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: Paxenopus 6; Polyclonal Antibody; Paxenopus 6 (Paired Boxenopus Protein Paxenopus-6; Oculorhombin; Paxenopus-6; Sey) (APC); anti-Pax6 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes mouse Paxenopus6. Species Crossreactivity: mouse
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-Pax6 antibody: Western Blot (WB)
• Application Notes: WB: 1:1000; Applications are based on unconjugated antibody.
• Immunogen: KLH conjugated synthetic peptide corresponding to aa404-436 at the C-terminal region of mouse Paxenopus6. Species sequence homology: bovine, chicken, zebrafish, human, rat, xenopus
• Conjugate: APC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-Pax6 antibody

Antibodies; Proteins

References

Walther C., et al. Development 113:1435-1449(1991). Favor J., et al. Genetics 159:1689-1700(2001). Carninci P., et al. Science 309:1559-1563(2005). Walther C., et al. Genomics 11:424-434(1991). Ton C.C.T., et al. Genomics 13:251-256(1992).

NCBI and Uniprot Product Information

• NCBI GI #: 346644677
• NCBI GeneID: 18508
• NCBI Accession #: NP_001231127.1
• NCBI GenBank Nucleotide #: NM_001244198.2
• UniProt Accession #: P63015; P55864; P63016; P26367; P26630; P47237; Q1LZF1
• Molecular Weight: 31,769 Da
• NCBI Official Full Name: paired box protein Pax-6 isoform 1
• NCBI Official Synonym Full Names: paired box 6
• NCBI Official Symbol: Pax6
• NCBI Official Synonym Symbols: Dey; Sey; AEY11; Pax-6; Gsfaey11; 1500038E17Rik
• NCBI Protein Information: paired box protein Pax-6
• UniProt Protein Name: Paired box protein Pax-6
• Protein Family: Paired box protein
• UniProt Gene Name: Pax6
• UniProt Synonym Gene Names: Pax-6; Sey

NCBI Description

This gene encodes a homeobox-containing protein that functions as a regulator of transcription. It plays a key role in the development of neural tissues, particularly the eye. Activity of this protein is also required for expression of glucagon in the pancreas. This gene is regulated by multiple enhancers located up to tens or hundreds of kilobases upstream and downstream of the transcription start sites. Mutations in this gene or deletion of these regulatory elements results in severe defects in eye development. Alternative splicing and the use of alternative promoters results in multiple transcript variants, some of which encode proteins that lack the N-terminal paired domain. [provided by RefSeq, Jul 2015]

Uniprot Description

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains ().