Western Blot (WB)
(PAX7 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PAX7 antibody detected the PAX7 protein (arrow).)
Rabbit PAX7 Polyclonal Antibody | anti-PAX7 antibody
PAX7 Antibody (Center)
IHC-P~~1:10~50
Western Blot (WB)
(PAX7 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PAX7 antibody detected the PAX7 protein (arrow).)
Western Blot (WB)
(PAX7 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PAX7 antibody detected the PAX7 protein (arrow).)
Immunohistochemistry (IHC)
(PAX7 Antibody (Center) (MBS9202728)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PAX7 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(PAX7 Antibody (Center) (MBS9202728)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PAX7 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Williamson, D., et al. J. Clin. Oncol. 28(13):2151-2158(2010)
Xynos, A., et al. Stem Cells 28(5):965-973(2010)
Edwards, T.L., et al. Ann. Hum. Genet. 74(2):97-109(2010)
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Uniprot Description
PAX7: Probable transcription factor. May have a role in myogenesis. Defects in PAX7 are a cause of rhabdomyosarcoma type 2 (RMS2). It is a form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. A chromosomal aberration involving PAX7 is found in rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator. Belongs to the paired homeobox family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 1p36.13
Cellular Component: nucleus
Molecular Function: sequence-specific DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; anatomical structure morphogenesis; positive regulation of histone methylation; satellite cell commitment; embryonic skeletal development; neuron fate commitment; skeletal muscle regeneration; chromatin remodeling; cartilage development; regulation of protein binding; regulation of cell fate commitment; spinal cord association neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; dorsoventral neural tube patterning; negative regulation of apoptosis
Disease: Rhabdomyosarcoma 2
Research Articles on PAX7
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Product Notes
The PAX7 pax7 (Catalog #AAA9202728) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 181-210. The PAX7 Antibody (Center) reacts with Reactivity: Human (Predicted: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's PAX7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), ELISA (EIA). WB~~1:1000 IHC-P~~1:10~50. Researchers should empirically determine the suitability of the PAX7 pax7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PAX7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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