Western Blot (WB)
(All lanes: Patatin-like phospholipase domain-containing protein 3 antibody at 8ug/ml+HepG2 whole cell lysateSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 53kDaObserved band size: 53kDa)
Rabbit anti-Human Patatin-like phospholipase domain-containing protein 3 Polyclonal Antibody | anti-PNPLA3 antibody
Rabbit anti-human Patatin-like phospholipase domain-containing protein 3 polyclonal Antibody(PNPLA3)
IHC:1:20-1:200
Western Blot (WB)
(All lanes: Patatin-like phospholipase domain-containing protein 3 antibody at 8ug/ml+HepG2 whole cell lysateSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 53kDaObserved band size: 53kDa)
Western Blot (WB)
(All lanes: Patatin-like phospholipase domain-containing protein 3 antibody at 8ug/ml+HepG2 whole cell lysateSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 53kDaObserved band size: 53kDa)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human skin using MBS1499072 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human skin using MBS1499072 at dilution 1:100)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]
Uniprot Description
PNPLA3: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 (NAFLD1). A condition characterized by an accumulation of excess triglyceride in the liver, a condition known as hepatic steatosis (or fatty liver), which is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Secondary Metabolites Metabolism - limonene and pinene degradation; Amino Acid Metabolism - phenylalanine; Lipid Metabolism - glycerolipid; Amino Acid Metabolism - tyrosine; EC 3.1.1.3; Phospholipase; Transferase; Lipid Metabolism - glycerophospholipid
Chromosomal Location of Human Ortholog: 22q13.31
Cellular Component: endoplasmic reticulum membrane; integral to membrane; membrane
Molecular Function: diolein transacylation activity; mono-olein transacylation activity; phospholipase A2 activity; triacylglycerol lipase activity
Biological Process: glycerophospholipid biosynthetic process; phospholipid metabolic process; triacylglycerol biosynthetic process; triacylglycerol catabolic process
Research Articles on PNPLA3
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Product Notes
The PNPLA3 pnpla3 (Catalog #AAA1499072) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Patatin-like phospholipase domain-containing protein 3 polyclonal Antibody(PNPLA3) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Patatin-like phospholipase domain-containing protein 3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Recommended dilution: WB:1:200-1000 IHC:1:20-1:200. Researchers should empirically determine the suitability of the PNPLA3 pnpla3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Patatin-like phospholipase domain-containing protein 3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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