Rabbit anti-Human, Rat0 PARK2 Co-regulated Polyclonal Antibody | anti-PACRG antibody

PARK2 Co-regulated (PACRG, PARK2CRG, FLJ32724, GLUP, HAK005771, RP3-495O10.2)

Cat. Num. AAA614921

• Gene Names: PACRG; GLUP; FLJ32724; PARK2CRG; HAK005771; RP3-495O10.2
• Reactivity: Human, Rat0
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: PARK2 Co-regulated; Polyclonal Antibody; PARK2 Co-regulated (PACRG; PARK2CRG; FLJ32724; GLUP; HAK005771; RP3-495O10.2); Anti -PARK2 Co-regulated (PACRG; anti-PACRG antibody

• Host: Rabbit
• Reactivity: Human, Rat0
• Clonality: Polyclonal
• Specificity: Recognizes Human PARK2 Co-regulated (PACRG). Species Crossreactivity: Human, Rat, Zebrafish.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.

• Applicable Applications for anti-PACRG antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Suitable for use in ELISA, Immunofluorescence, Immunohistochemistry and Western Blot.; Dilution: Immunohistochemistry: 1.5-2.5ug/ml; Western Blot: 1:500-1:3000; ELISA: 1:2000-1:10,000
• Immunogen: Synthetic peptide, KLH-conjugated. Epitope: Amino acids 204-215 of Human PACRG protein.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Immunohistochemistry (IHC)

(PACRG (5ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human colon, followed by biotinylated goat rabbit IgG secondary, alkaline phosphatase-streptavidin and chromogen.)

Product Categories/Family for anti-PACRG antibody

Antibodies; Abs to Binding Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 28279821
• NCBI GeneID: 135138
• UniProt Accession #: Q96M98; Q6IMB8; Q8IZM1; Q8NHP5; Q9H1V9; E1P5B5
• Molecular Weight: 33,342 Da
• NCBI Official Full Name: PARK2 co-regulated
• NCBI Official Synonym Full Names: PARK2 co-regulated
• NCBI Official Symbol: PACRG
• NCBI Official Synonym Symbols: GLUP; FLJ32724; PARK2CRG; HAK005771; RP3-495O10.2
• NCBI Protein Information: parkin coregulated gene protein; OTTHUMP00000017729; OTTHUMP00000017730; OTTHUMP00000239114; PARK2 coregulated gene protein; parkin co-regulated gene protein; molecular chaperone/chaperonin-binding protein
• UniProt Protein Name: Parkin coregulated gene protein
• Protein Family: Parkin coregulated gene protein
• UniProt Gene Name: PACRG
• UniProt Synonym Gene Names: GLUP
• UniProt Entry Name: PACRG_HUMAN

NCBI Description

This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Uniprot Description

PACRG: Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 6q26

Cellular Component: neuron projection; mitochondrion; cytosol; nucleus; vesicle

Molecular Function: G-protein-coupled receptor binding; chaperone binding; ubiquitin protein ligase binding; heat shock protein binding; beta-tubulin binding; Hsp90 protein binding; Hsp70 protein binding; actin binding; alpha-tubulin binding

Biological Process: spermatid development

Disease: Leprosy, Susceptibility To, 2