Western Blot (WB)
(Western blot (WB) analysis of PAR4 polyclonal antibody at 1:500 dilutionLaneA: COS-7 whole cell lysateLaneB: CT26 whole cell lysate)
Rabbit anti-Human, Mouse PAR4 Polyclonal Antibody | anti-PAR4 antibody
PAR4 polyclonal antibody
IHC: 1:50~1:200
Western Blot (WB)
(Western blot (WB) analysis of PAR4 polyclonal antibody at 1:500 dilutionLaneA: COS-7 whole cell lysateLaneB: CT26 whole cell lysate)
Western Blot (WB)
(Western blot (WB) analysis of PAR4 polyclonal antibody at 1:500 dilutionLaneA: COS-7 whole cell lysateLaneB: CT26 whole cell lysate)
NCBI and Uniprot Product Information
NCBI Description
Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin. [provided by RefSeq, Jul 2008]
Uniprot Description
PAR4: a G-protein coupled receptor for activated thrombin or trypsin. Coupled to G proteins that stimulate phosphoinositide hydrolysis. Plays a role in platelets activation. Thrombin requires PAR4 for full spreading on a fibrinogen matrix. Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets. A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 19p12
Cellular Component: integral to plasma membrane; plasma membrane; extracellular region
Molecular Function: thrombin receptor activity
Biological Process: platelet activation; platelet dense granule organization and biogenesis; response to wounding; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of release of sequestered calcium ion into cytosol; blood coagulation; signal transduction
Research Articles on PAR4
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Product Notes
The PAR4 f2rl3 (Catalog #AAA3014974) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PAR4 polyclonal antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PAR4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500~1:1000 IHC: 1:50~1:200. Researchers should empirically determine the suitability of the PAR4 f2rl3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PAR4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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