Rabbit anti-Human PAPPA2 Polyclonal Antibody | anti-PAPPA2 antibody

PAPPA2, NT (Pappalysin-2, Pregnancy-associated Plasma Protein A2, PAPP-A2, Pregnancy-associated Plasma Protein E1, PAPP-E, PLAC3)

Cat. Num. AAA649288

• Gene Names: PAPPA2; PAPPE; PLAC3; PAPP-E; PAPP-A2
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: PAPPA2; Polyclonal Antibody; NT (Pappalysin-2; Pregnancy-associated Plasma Protein A2; PAPP-A2; Pregnancy-associated Plasma Protein E1; PAPP-E; PLAC3); Anti -PAPPA2; anti-PAPPA2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human PAPPA2. Species sequence homology: mouse and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-PAPPA2 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot and Immunohistochemistry.; Dilution: Western Blot: 1-2ug/ml; Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
• Immunogen: Synthetic peptide corresponding to 15aa from human PLAC3 at N-terminus.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-PAPPA2 antibody

Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.

Product Categories/Family for anti-PAPPA2 antibody

Antibodies; Abs to Hormones; Steroids

NCBI and Uniprot Product Information

• NCBI GI #: 116174738
• NCBI GeneID: 60676
• NCBI Accession #: NP_064714.2
• NCBI GenBank Nucleotide #: NM_020318.2
• UniProt Accession #: Q9BXP8; Q96PH7; Q96PH8; Q9H4C9; A9Z1Y8
• Molecular Weight: 198,539 Da
• NCBI Official Full Name: pappalysin-2 isoform 1
• NCBI Official Synonym Full Names: pappalysin 2
• NCBI Official Symbol: PAPPA2
• NCBI Official Synonym Symbols: PAPPE; PLAC3; PAPP-E; PAPP-A2
• NCBI Protein Information: pappalysin-2; placenta-specific 3; pregnancy-associated plasma protein E1; pregnancy-associated plasma preproprotein-A2
• UniProt Protein Name: Pappalysin-2
• Protein Family: Pappalysin
• UniProt Gene Name: PAPPA2
• UniProt Synonym Gene Names: PLAC3; PAPP-A2; PAPP-E
• UniProt Entry Name: PAPP2_HUMAN

NCBI Description

This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

Uniprot Description

Function: Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3. Ref.1

Catalytic activity: Cleavage of the 143-Ser-|-Lys-144 bond in insulin-like growth factor binding protein (IGFBP)-5.

Cofactor: Binds 1 zinc ion per subunit

By similarity.

Subunit structure: Monomer.

Subcellular location: Secreted

By similarity.

Tissue specificity: Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas. Ref.1 Ref.2

Sequence similarities: Belongs to the peptidase M43B family.Contains 5 Sushi (CCP/SCR) domains.

Sequence caution: The sequence AAL17779.1 differs from that shown. Reason: Erroneous initiation. The sequence AAL17780.1 differs from that shown. Reason: Erroneous initiation. The sequence CAC11134.1 differs from that shown. Reason: Erroneous initiation.