Western Blot (WB)
(Western blot analysis of extracts of various cells, using PANX1 antibody.)
Rabbit anti-Human PANX1 Polyclonal Antibody | anti-PANX1 antibody
PANX1 Polyclonal Antibody
Western Blot (WB)
(Western blot analysis of extracts of various cells, using PANX1 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of various cells, using PANX1 antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cell using PANX1 antibody. Blue: DAPI for nuclear staining.)
Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cell using PANX1 antibody. Blue: DAPI for nuclear staining.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]
Uniprot Description
PANX1: Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. Belongs to the pannexin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q21
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; gap junction; integral to membrane; membrane; plasma membrane; protein complex
Molecular Function: actin filament binding; calcium channel activity; gap junction hemi-channel activity; leak channel activity; protease binding; protein heterodimerization activity; receptor binding
Biological Process: calcium ion transport; cation transport; cell-cell signaling; innate immune response; positive regulation of interleukin-1 alpha secretion; positive regulation of interleukin-1 beta secretion; response to ATP; synaptic transmission
Research Articles on PANX1
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Product Notes
The PANX1 panx1 (Catalog #AAA2534763) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PANX1 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PANX1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-1:100. Researchers should empirically determine the suitability of the PANX1 panx1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PANX1 , Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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