Rabbit PAK7 Polyclonal Antibody | anti-PAK7 antibody

Rabbit Polyclonal to Human PAK7

Cat. Num. AAA246773

• Gene Names: PAK7; PAK5
• Reactivity: Gorilla, Human; Predicted Reactivity: Orangutan, Gibbon, Monkey (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: PAK7; Polyclonal Antibody; Rabbit Polyclonal to Human PAK7; Anti-PAK7 Antibody (Internal) IHC-plus; p21(CDKN1A)-activated kinase 7; p21CDKN1A-activated kinase 7; PAK-7; PAK5; KIAA1264; p21-activated kinase 5; PAK-5; p21-activated kinase 7; Protein kinase PAK5; Human PAK7; anti-PAK7 antibody

• Host: Rabbit
• Reactivity: Gorilla, Human; Predicted Reactivity: Orangutan, Gibbon, Monkey (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human PAK7. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 719

• Applicable Applications for anti-PAK7 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (5 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 20 amino acid peptide from internal region of human PAK7. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Orangutan, Gibbon, Monkey (95%); Marmoset (90%).
• Immunogen Type: Synthetic peptide
• Immunogen: PAK7 antibody was raised against synthetic 20 amino acid peptide from internal region of human PAK7. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Orangutan, Gibbon, Monkey (95%); Marmoset (90%).
• Antigen Modification: Internal
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-PAK7 antibody IHC of human brain, thalamus neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-PAK7 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-PAK7 antibody IHC of human brain, substantia nigra neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-PAK7 antibody

PAK5, a PAK (STE20) type protein kinase, contains a N-terminal Cdc42/Rac interactive binding (CRIB) motif and a C-terminal kinase domain. The protein is a target of the Rho GTPases Cdc42 and Rac; however, binding of Cdc42 is not required for kinase activity.

Product Categories/Family for anti-PAK7 antibody

Family: Protein Kinase; Subfamily: PAK (STE20)

NCBI and Uniprot Product Information

• NCBI GI #: 24308191
• NCBI GeneID: 57144
• NCBI Accession #: NP_065074.1
• NCBI GenBank Nucleotide #: NM_020341.3
• UniProt Accession #: Q9P286; Q5W115; Q9BX09; Q9ULF6; A8K5T6; D3DW14
• Molecular Weight: 80,745 Da
• NCBI Official Full Name: serine/threonine-protein kinase PAK 7
• NCBI Official Synonym Full Names: p21 protein (Cdc42/Rac)-activated kinase 7
• NCBI Official Symbol: PAK7
• NCBI Official Synonym Symbols: PAK5
• NCBI Protein Information: serine/threonine-protein kinase PAK 7; PAK-5; PAK-7; protein kinase PAK5; p21-activated kinase 5; p21-activated kinase 7; p21CDKN1A-activated kinase 7; serine/threonine-protein kinase PAK7
• UniProt Protein Name: Serine/threonine-protein kinase PAK 7
• UniProt Gene Name: PAK7
• UniProt Synonym Gene Names: KIAA1264; PAK5; PAK-5; PAK-7
• UniProt Entry Name: PAK7_HUMAN

NCBI Description

The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

PAK5: a protein kinase of the STE20 family. Predominantly expressed in brain. Capable of promoting neurite outgrowth, and thus may play a role in neurite development. Associated with microtubule networks and induces microtubule stabilization. Its subcellular localization is tightly regulated during cell cycle progression.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, STE; STE group; STE20 family; PAKB subfamily

Chromosomal Location of Human Ortholog: 20p12

Cellular Component: mitochondrion; cytoplasm; nucleus

Molecular Function: ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: cell proliferation; cell migration; apoptosis; locomotory behavior; cytoskeleton organization and biogenesis; learning; mitotic cell cycle; cell growth; signal transduction; protein amino acid phosphorylation; memory