Rabbit PAK6 Polyclonal Antibody | anti-PAK6 antibody

Rabbit Polyclonal to Human PAK6

Cat. Num. AAA244590

• Gene Names: PAK6; PAK5
• Reactivity: Gibbon, Gorilla, Human, Orangutan; Predicted Reactivity: Monkey, Bovine (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: PAK6; Polyclonal Antibody; Rabbit Polyclonal to Human PAK6; Anti-PAK6 Antibody (Linker Domain) IHC-plus; PAK5; p21-activated kinase 6; p21-activated protein kinase 6; PAK-5; PAK-6; p21(CDKN1A)-activated kinase 6; Human PAK6; anti-PAK6 antibody

• Host: Rabbit
• Reactivity: Gibbon, Gorilla, Human, Orangutan; Predicted Reactivity: Monkey, Bovine (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human PAK6. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except AGBL5 (42%).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 681

• Applicable Applications for anti-PAK6 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (4.8 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 19 amino acid peptide from Linker domain of human PAK6. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon (100%); Monkey, Panda, Bovine (95%); Marmoset, Rat, Elephant, Bat, Dog, Rabbit, Horse (89%).
• Immunogen Type: Synthetic peptide
• Immunogen: PAK6 antibody was raised against synthetic 19 amino acid peptide from Linker domain of human PAK6. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon (100%); Monkey, Panda, Bovine (95%); Marmoset, Rat, Elephant, Bat, Dog, Rabbit, Horse (89%); Mouse (84%).
• Antigen Modification: Linker Domain
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-PAK6 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-PAK6 antibody

PAK6, a PAK (STE20) type protein kinase, contains a N-terminal Cdc42/Rac interactive binding (CRIB) motif and a C-terminal kinase domain. The protein has been shown to bind to GTP-Cdc42 and GTP-Rac; however, in contrast to most PAKs, kinase activity was not stimulated by Cdc42 or Rac, but could be stimulated by androgen receptor (AR) binding. PAK6 protein also has been shown to bind to estrogen receptor alpha.

Product Categories/Family for anti-PAK6 antibody

Family: Protein Kinase; Subfamily: PAK (STE20)

NCBI and Uniprot Product Information

• NCBI GI #: 9910476
• NCBI GeneID: 56924
• NCBI Accession #: NP_064553.1
• NCBI GenBank Nucleotide #: NM_020168.5
• UniProt Accession #: Q9NQU5; A8K2G2; B3KYB0; G5E9R2
• Molecular Weight: 69,777 Da
• NCBI Official Full Name: serine/threonine-protein kinase PAK 6 isoform 1
• NCBI Official Synonym Full Names: p21 protein (Cdc42/Rac)-activated kinase 6
• NCBI Official Symbol: PAK6
• NCBI Official Synonym Symbols: PAK5
• NCBI Protein Information: serine/threonine-protein kinase PAK 6; p21(CDKN1A)-activated kinase 6
• UniProt Protein Name: Serine/threonine-protein kinase PAK 6
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: PAK6
• UniProt Synonym Gene Names: PAK5; PAK-6
• UniProt Entry Name: PAK6_HUMAN

NCBI Description

This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Uniprot Description

PAK6: a protein kinase of the STE20 family. Interacts with androgen receptor (AR), and cotranslocates into the nucleus with AR in response to androgen. Highly expressed in testis and prostate tissues.

Protein type: Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; STE group; STE20 family; PAKB subfamily

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: regulation of transcription, DNA-dependent; apoptosis; cytoskeleton organization and biogenesis; mitotic cell cycle; protein amino acid phosphorylation