Western Blot (WB)
(Western blot analysis of PAK3 expression in rat brain extract (lane 1) and mouse brain extract (lane 2). PAK3 at 62KD was detected using rabbit anti- PAK3 Antigen Affinity purified polyclonal antibody at 0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method. )
PAK3 Polyclonal Antibody | anti-PAK3 antibody
Anti-PAK3 Antibody
Predicted to work with: Human
Predicted to work with: Human
Western Blot (WB)
(Western blot analysis of PAK3 expression in rat brain extract (lane 1) and mouse brain extract (lane 2). PAK3 at 62KD was detected using rabbit anti- PAK3 Antigen Affinity purified polyclonal antibody at 0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method. )
Western Blot (WB)
(Western blot analysis of PAK3 expression in rat brain extract (lane 1) and mouse brain extract (lane 2). PAK3 at 62KD was detected using rabbit anti- PAK3 Antigen Affinity purified polyclonal antibody at 0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method. )
Background: Nucleobindin-2 is a calcium-binding EF-hand protein that in humans is encoded by the NUCB2 gene. By exon trapping and sequence analysis, the NUCB2 sequence has been identified on chromosome 11p15-p14. This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Apr 2016]
Uniprot Description
PAK3: a protein kinase of the STE20 family that regulates synapse formation and plasticity in the hippocampus. May be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Forms an activated complex with GTP-bound P21, CDC2 and RAC1 proteins. Missense and truncation mutations linked to nonsyndromic mental retardation type 30 (MRX30). Two alternatively spliced human isoforms have been reported.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, STE; STE group; STE20 family; PAKA subfamily
Chromosomal Location of Human Ortholog: Xq23
Cellular Component: cytoplasm; cytosol; endosome; plasma membrane
Molecular Function: ATP binding; MAP kinase kinase activity; metal ion binding; protein binding; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity; Rho GTPase binding; SH3 domain binding
Biological Process: activation of MAPK activity; axonogenesis; dendrite development; ephrin receptor signaling pathway; MAPKKK cascade; mitotic cell cycle; positive regulation of neuron apoptosis; regulation of actin filament polymerization; stimulatory C-type lectin receptor signaling pathway; synapse organization and biogenesis; T cell costimulation; T cell receptor signaling pathway
Disease: Mental Retardation, X-linked 30
Research Articles on PAK3
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Product Notes
The PAK3 pak3 (Catalog #AAA178167) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-PAK3 Antibody reacts with Mouse, Rat Predicted to work with: Human and may cross-react with other species as described in the data sheet. AAA Biotech's PAK3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot Concentration: 0.1-0.5ug/ml. Researchers should empirically determine the suitability of the PAK3 pak3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PAK3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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