Sheep anti-Human Paired Immunoglobulin-Like Type 2 Receptor beta Polyclonal Antibody | anti-PILRB antibody

Paired Immunoglobulin-Like Type 2 Receptor beta (PILRb) (Biotin)

Cat. Num. AAA610171

• Gene Names: PILRB; FDFACT1; FDFACT2
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Paired Immunoglobulin-Like Type 2 Receptor beta; Polyclonal Antibody; Paired Immunoglobulin-Like Type 2 Receptor beta (PILRb) (Biotin); Anti -Paired Immunoglobulin-Like Type 2 Receptor beta (PILRb) (Biotin); anti-PILRB antibody

• Host: Sheep
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Paired lgG-Like Type 2 Receptor b.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a lyophilized powder from (PBS) containing 50ug of bovine serum albumin (BSA). Labeled with Biotin. Reconstitute with 200ul 40-50% glycerol, PBS.

• Applicable Applications for anti-PILRB antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 0.1-0.2 ug/mL detection limit for rhPILR-b ~ 1ng/lane under non-reducing and reducing conditions.
• Immunogen: NS0-derived, recombinant human Paired lgG-Like Type 2 Receptor b.
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-PILRB antibody

Paired immunoglobulin-like, type 2 receptor beta (PILR-b) is a type I transmembrane (TM) glycoprotein belonging to the Ig superfamily. It is the activating counterpart to the ITIM-bearing PILR-a inhibitory receptor. PILR-b is expressed in a wide variety of tissues including hematopoietic cells. Mature human PILR-b is a 208 amino acid (aa) protein with one V-type Ig-like extracellular domain, a truncated cytoplasmic tail, and positively-charged residues in its TM domain that interacts with ITAM-bearing adaptor molecules. Within the V-type Ig-like region in their ECD, human PILR-b and PILR-a share a 92% aa sequence identity. The aa sequence of mouse PILR-b ECD is only 43% identical to that of the human protein.

Product Categories/Family for anti-PILRB antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 30179915
• NCBI GeneID: 29990
• UniProt Accession #: Q9UKJ0; Q69YF9; Q9HBS0; Q8TET2
• Molecular Weight: 25,542 Da
• NCBI Official Full Name: paired immunoglobulin-like type 2 receptor beta isoform a [Homo sapiens]
• NCBI Official Synonym Full Names: paired immunoglobin-like type 2 receptor beta
• NCBI Official Symbol: PILRB
• NCBI Official Synonym Symbols: FDFACT1; FDFACT2
• NCBI Protein Information: paired immunoglobulin-like type 2 receptor beta; activating receptor PILRbeta; cell surface receptor FDFACT; activating receptor PILR-beta; cell surface receptor FDFACT1; cell surface receptor FDFACT2; paired immunoglobin-like receptor beta; paired immunoglobulin-like receptor beta
• UniProt Protein Name: Paired immunoglobulin-like type 2 receptor beta
• Protein Family: Paired immunoglobulin-like type 2 receptor
• UniProt Gene Name: PILRB
• UniProt Synonym Gene Names: FDFACT
• UniProt Entry Name: PILRB_HUMAN

NCBI Description

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner, and functions in the activating role. Alternatively spliced transcript variants have been noted for this gene, but the full-length nature of many is not known. [provided by RefSeq]

Uniprot Description

PILRB: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: integral to plasma membrane

Molecular Function: protein binding

Biological Process: transmembrane receptor protein tyrosine kinase activation (dimerization); transmembrane receptor protein tyrosine kinase signaling pathway