Rabbit PAIP2 Polyclonal Antibody | anti-PAIP2 antibody

PAIP2 Antibody

Cat. Num. AAA9629820

• Gene Names: PAIP2; PAIP-2; PAIP2A
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: PAIP2; Polyclonal Antibody; PAIP2 Antibody; anti-PAIP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: PAIP2 Antibody detects endogenous levels of PAIP2.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-PAIP2 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human PAIP2.
• Conjugation: Unconjugated
• Similarity: Only the PABPC1-interacting motif-1 (PAM1) interferes with the binding of PABPC1 to poly(A) RNA and translation initiation. Belongs to the PAIP2 family.
• Post Translational Modifications: Ubiquitinated, leading to its degradation by the proteasome.
• Subunit Structure: Interacts with the second and third RRM domains and C-terminus regions of PABPC1 in a 2:1 stoichiometry.
• Tissue Specificity: Expressed at highest level in testis, but also abundant in brain, cervix, lung, ovary, placenta, adipose tissue, thymus and thyroid.
• Function: Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-PAIP2 antibody

Cytoplasm; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 75677355
• NCBI GeneID: 51247
• NCBI Accession #: NP_001028284.1
• NCBI GenBank Nucleotide #: NM_001033112.2
• UniProt Accession #: Q9BPZ3; Q49A06; Q9H0Y5; Q9P0Q8; B2RBI1; D3DQC6
• Molecular Weight: 14,984 Da
• NCBI Official Full Name: polyadenylate-binding protein-interacting protein 2
• NCBI Official Synonym Full Names: poly(A) binding protein interacting protein 2
• NCBI Official Symbol: PAIP2
• NCBI Official Synonym Symbols: PAIP-2; PAIP2A
• NCBI Protein Information: polyadenylate-binding protein-interacting protein 2; PABC1-interacting protein 2; PABP-interacting protein 2; polyA-binding protein-interacting protein 2
• UniProt Protein Name: Polyadenylate-binding protein-interacting protein 2
• Protein Family: Polyadenylate-binding protein-interacting protein
• UniProt Gene Name: PAIP2
• UniProt Synonym Gene Names: PAIP2A; PABP-interacting protein 2; PAIP-2; Poly(A)-binding protein-interacting protein 2
• UniProt Entry Name: PAIP2_HUMAN

Uniprot Description

PAIP2: Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. Interacts with the second and third RRM domains and C- terminus regions of PABPC1 in a 2:1 stoichiometry. Belongs to the PAIP2 family.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: cytoplasm

Molecular Function: mRNA binding; protein binding; translation repressor activity

Biological Process: negative regulation of translational initiation; spermatogenesis; memory