Rabbit anti-Human, Mouse PAG1 / PAG Polyclonal Antibody | anti-PAG1 antibody

Rabbit Polyclonal to Human PAG1 / PAG

Cat. Num. AAA242233

• Gene Names: PAG1; CBP; PAG
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Western Blot, Immunoprecipitation
• Purity: Precipitation
• Synonyms: PAG1 / PAG; Polyclonal Antibody; Rabbit Polyclonal to Human PAG1 / PAG; Anti-PAG1 / PAG Antibody (aa97-432) IHC-plus; PAG1; Csk-binding protein; CBP; PAG; Human PAG1; anti-PAG1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: Recognizes Csk-binding protein (Cbp / PAG), a 46 kD ubiquitously expressed transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kD molecule.
• Purity/Purification: Precipitation
• Form/Format: PBS, 15 mM sodium azide, approx., pH 7.4.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 432

• Applicable Applications for anti-PAG1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: IHC-P (10 ug/ml), IP, WB; Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Recombinant intracellular fragment (aa 97-432) of human Cbp (PAG).
• Immunogen Type: Recombinant protein
• Immunogen: PAG1 / PAG antibody was raised against recombinant intracellular fragment (aa 97-432) of human Cbp (PAG).
• Antigen Modification: aa97-432
• Preparation and Storage: +4 degree C or -20 degree C, Avoid repeated freezing and thawing.

Immunohistochemistry (IHC)

(Anti-PAG1 / PAG antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 63054864
• NCBI GeneID: 55824
• NCBI Accession #: NP_060910.3
• NCBI GenBank Nucleotide #: NM_018440.3
• UniProt Accession #: Q9NWQ8; Q2M1Z9; Q5BKU4; Q9NYK0; A8K1A3
• Molecular Weight: 46,981 Da
• NCBI Official Full Name: phosphoprotein associated with glycosphingolipid-enriched microdomains 1
• NCBI Official Synonym Full Names: phosphoprotein membrane anchor with glycosphingolipid microdomains 1
• NCBI Official Symbol: PAG1
• NCBI Official Synonym Symbols: CBP; PAG
• NCBI Protein Information: phosphoprotein associated with glycosphingolipid-enriched microdomains 1; Csk-binding protein; transmembrane phosphoprotein Cbp; transmembrane adapter protein PAG; transmembrane adaptor protein PAG; phosphoprotein associated with glycosphingolipid microdomains 1
• UniProt Protein Name: Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
• Protein Family: Protein
• UniProt Gene Name: PAG1
• UniProt Synonym Gene Names: CBP; PAG
• UniProt Entry Name: PHAG1_HUMAN

NCBI Description

The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]

Uniprot Description

PAG: an ubiquitous type III transmembrane adaptor protein that binds to the tyrosine kinase CSK protein. It is thought to be involved in the regulation of T cell activation.

Protein type: Membrane protein, integral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 8q21.13

Cellular Component: integral to membrane; plasma membrane; lipid raft

Molecular Function: protein binding; SH3/SH2 adaptor activity; SH2 domain binding

Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of signal transduction; signal transduction; negative regulation of T cell activation; T cell receptor signaling pathway; regulation of T cell activation