Rabbit PAEP Polyclonal Antibody | anti-PAEP antibody

PAEP Polyclonal Antibody

Cat. Num. AAA9134749

• Gene Names: PAEP; GD; GdA; GdF; GdS; PEP; PAEG; PP14; ZIF-1
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Affinity Purification
• Synonyms: PAEP; Polyclonal Antibody; PAEP Polyclonal Antibody; GD; GdA; GdF; GdS; PAEG; PEP; PP14; anti-PAEP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Sequence Length: 158

• Applicable Applications for anti-PAEP antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50 - 1:200
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 19-180 of human PAEP
• Preparation and Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human stomach using PAEP antibody (MBS9134749) at dilution of 1:100 (40x lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse pancreas using PAEP antibody (MBS9134749) at dilution of 1:100 (40x lens).)

Related Product Information for anti-PAEP antibody

This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants.

Product Categories/Family for anti-PAEP antibody

Polyclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 937226996
• NCBI GeneID: 5047
• NCBI Accession #: NP_001018058.1
• NCBI GenBank Nucleotide #: NM_001018048.1
• UniProt Accession #: P09466; Q5T6T1; Q9UG92
• Molecular Weight: Calculated MW: 9kDa/18kDa/20kDa
• NCBI Official Full Name: glycodelin isoform 2
• NCBI Official Synonym Full Names: progestagen associated endometrial protein
• NCBI Official Symbol: PAEP
• NCBI Official Synonym Symbols: GD; GdA; GdF; GdS; PEP; PAEG; PP14; ZIF-1
• NCBI Protein Information: glycodelin
• UniProt Protein Name: Glycodelin
• Protein Family: Glycodelin
• UniProt Gene Name: PAEP
• UniProt Synonym Gene Names: ZIF-1

NCBI Description

This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Uniprot Description

Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:9918684, PubMed:7531163). Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260). Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671). Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155).