Rabbit anti-Human PABPN1 Polyclonal Antibody | anti-PABPN1 antibody

PABPN1 Antibody - C-terminal region

Cat. Num. AAA3219795

• Gene Names: PABPN1; OPMD; PAB2; PABII; PABP2; PABP-2
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity purified
• Synonyms: PABPN1; Polyclonal Antibody; PABPN1 Antibody - C-terminal region; anti-PABPN1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Affinity purified
• Form/Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 16% sucrose.
• Sequence: Synthetic peptide located within the following region: NRPGISTTDRGFPRARYRARTTNYNSSRSRFYSGFNSRPRGRVYRGRARA
• Sequence Length: 333

• Applicable Applications for anti-PABPN1 antibody: Western Blot (WB)
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PABPN1
• Preparation and Storage: For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Host: RabbitTarget Name: PABPN1Sample Tissue: MCF7 Whole Cell lysatesAntibody Dilution: 1ug/ml)

Related Product Information for anti-PABPN1 antibody

This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.

Product Categories/Family for anti-PABPN1 antibody

Polyclonal; RNA Binding Proteins; Cell Biology; Chromatin & Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 4758876
• NCBI GeneID: 8106
• NCBI Accession #: NP_004634.1
• NCBI GenBank Nucleotide #: NM_001199839.1
• UniProt Accession #: Q92843; Q86U42
• Molecular Weight: 36 kDa
• NCBI Official Full Name: polyadenylate-binding protein 2 isoform 1
• NCBI Official Synonym Full Names: poly(A) binding protein nuclear 1
• NCBI Official Symbol: PABPN1
• NCBI Official Synonym Symbols: OPMD; PAB2; PABII; PABP2; PABP-2
• NCBI Protein Information: polyadenylate-binding protein 2
• UniProt Protein Name: Bcl-2-like protein 2
• UniProt Gene Name: BCL2L2
• UniProt Synonym Gene Names: BCLW; KIAA0271; Bcl2-L-2
• UniProt Entry Name: B2CL2_HUMAN

NCBI Description

This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq, Dec 2010]

Uniprot Description

BCL2L2: Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. Expressed in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines. Belongs to the Bcl-2 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q11.2-q12

Cellular Component: mitochondrial outer membrane; cytosol

Molecular Function: BH domain binding; protein binding; protein homodimerization activity; protein heterodimerization activity

Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; Sertoli cell proliferation; spermatogenesis; negative regulation of apoptosis