Rabbit anti-Human P2Y2 Receptor Polyclonal Antibody | anti-P2RY2 antibody

P2Y2 Receptor (Human P2U Nucleotide Receptor, HP2U, MGC20088, MGC40010, P2RU1, P2RY2, P2U Nucleotide Receptor, P2U Purinoceptor 1, P2U1, P2UR, P2Y Purinoceptor 2, P2Y2R, Purinergic Receptor P2Y G Protein-coupled 2, Purinergic Receptor P2Y2, Purinoceptor P

Cat. Num. AAA618466

• Gene Names: P2RY2; P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R; MGC20088; MGC40010
• Reactivity: Human
• Applications: Western Blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: P2Y2 Receptor; Polyclonal Antibody; P2Y2 Receptor (Human P2U Nucleotide Receptor; HP2U; MGC20088; MGC40010; P2RU1; P2RY2; P2U Nucleotide Receptor; P2U Purinoceptor 1; P2U1; P2UR; P2Y Purinoceptor 2; P2Y2R; Purinergic Receptor P2Y G Protein-coupled 2; Purinergic Receptor P2Y2; Purinoceptor P; Anti -P2Y2 Receptor (Human P2U Nucleotide Receptor; anti-P2RY2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human P2Y2 Receptor. Species Crossreactivity: mouse and rat
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS (pH 7.2) containing 0.05% sodium azide.

• Applicable Applications for anti-P2RY2 antibody: Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry(IHC). Other applications not tested.
• Application Notes: Immunocytochemistry/Immunofluorescence: 1:50 -1:100; Immunohistochemistry (paraffin): 1:100 - 1:200; Western Blot: 1:500 -1:1,000; Optimal dilutions to be determined by the researcher.
• Immunogen: Synthetic peptide comprising residues 351-366 [DVLGSSEDSRRTESTP] of the human P2Y2 protein.
• Positive Control: Human brain lysate and rat dorsal root ganglion
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(WB analysis using MBS618466: Lane 1: human testis tissue homogenate Lane 2: human kidney tissue homogenate Lane 3: human liver tissue homogenate Lane 4: human lung tissue homogenate Lane 5: human heart tissue homogenate)

Immunohistochemistry (IHC)

(IHC staining of paraffin-embedded mouse brain using MBS618466.)

Related Product Information for anti-P2RY2 antibody

P2Y2 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. P2Y2 is also a morphogen receptor that potentiates neurotrophin signaling in neuronal development and regeneration.

Product Categories/Family for anti-P2RY2 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 28872745
• NCBI GeneID: 5029
• NCBI Accession #: NP_788086.1
• NCBI GenBank Nucleotide #: NM_176072.1
• UniProt Accession #: P41231; Q96EM8; B2R9W3
• Molecular Weight: 42,273 Da
• NCBI Official Full Name: P2Y purinoceptor 2
• NCBI Official Synonym Full Names: purinergic receptor P2Y, G-protein coupled, 2
• NCBI Official Symbol: P2RY2
• NCBI Official Synonym Symbols: P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R; MGC20088; MGC40010
• NCBI Protein Information: P2Y purinoceptor 2; ATP receptor; purinoceptor P2Y2; OTTHUMP00000237494; OTTHUMP00000237495; OTTHUMP00000237496; P2U purinoceptor 1; P2U nucleotide receptor; purinergic receptor P2Y2
• UniProt Protein Name: P2Y purinoceptor 2
• Protein Family: P2Y purinoceptor
• UniProt Gene Name: P2RY2
• UniProt Synonym Gene Names: P2RU1
• UniProt Entry Name: P2RY2_HUMAN

NCBI Description

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]

Uniprot Description

P2Y2: a G-protein coupled receptor of the rhodopsin family. This family includes hormone, neurotransmitter and light receptors. Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP. May participate in control of the cell cycle and proliferation.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 11q13.5-q14.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: purinergic nucleotide receptor activity, G-protein coupled; receptor activity

Biological Process: cellular ion homeostasis; regulation of vasodilation; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)