Rabbit anti-Human P2RY2 Polyclonal Antibody | anti-P2RY2 antibody

P2RY2, CT (P2RY2, P2RU1, P2Y purinoceptor 2, ATP receptor, P2U purinoceptor 1, Purinergic receptor) (Azide free) (HRP)

Cat. Num. AAA6330278

• Gene Names: P2RY2; P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: P2RY2; Polyclonal Antibody; CT (P2RY2; P2RU1; P2Y purinoceptor 2; ATP receptor; P2U purinoceptor 1; Purinergic receptor) (Azide free) (HRP); Purinergic receptor; anti-P2RY2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human P2RY2.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-P2RY2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 324-352 in the C-terminal region of human P2RY2, UniProt Accession #P41231.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in CEM cell line lysates (35ug/lane) usingMBS6002521. This demonstrates that MBS6002521 detected the P2RY2 protein (arrow).)

Related Product Information for anti-P2RY2 antibody

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.

Product Categories/Family for anti-P2RY2 antibody

Antibodies; Receptors

References

1. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). 2. Boucher, I., et al. Am. J. Physiol., Cell Physiol. 299 (2), C411-C421 (2010). 3. Ratchford, A.M., et al. J. Biol. Chem. 285(10):7545-7555(2010). 4. Taboubi, S., et al. Mol. Biol. Cell 21(6):946-955(2010). 5. Vazquez-Cuevas, F.G., et al. Reprod. Biol. Endocrinol. 8, 88 (2010).

NCBI and Uniprot Product Information

• NCBI GI #: 28872720
• NCBI GeneID: 5029
• NCBI Accession #: NP_002555.2; NP_788086.1; NP_788085.1
• NCBI GenBank Nucleotide #: NM_002564.2
• UniProt Accession #: P41231; Q96EM8; B2R9W3
• Molecular Weight: 42,273 Da
• NCBI Official Full Name: P2Y purinoceptor 2
• NCBI Official Synonym Full Names: purinergic receptor P2Y, G-protein coupled, 2
• NCBI Official Symbol: P2RY2
• NCBI Official Synonym Symbols: P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R
• NCBI Protein Information: P2Y purinoceptor 2; ATP receptor; purinoceptor P2Y2; P2U purinoceptor 1; P2U nucleotide receptor; purinergic receptor P2Y2
• UniProt Protein Name: P2Y purinoceptor 2
• Protein Family: P2Y purinoceptor
• UniProt Gene Name: P2RY2
• UniProt Synonym Gene Names: P2RU1; P2Y2; P2U1
• UniProt Entry Name: P2RY2_HUMAN

NCBI Description

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]