Rabbit anti-Mouse, Rat P2Y1 Receptor Polyclonal Antibody | anti-P2RY1 antibody

P2Y1 Receptor (P2RY1) (C-terminus)

Cat. Num. AAA618721

• Gene Names: P2RY1; P2Y1
• Reactivity: Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Purified; Purified by epitope affinity chromatography.
• Synonyms: P2Y1 Receptor; Polyclonal Antibody; P2Y1 Receptor (P2RY1) (C-terminus); Anti -P2Y1 Receptor (P2RY1) (C-terminus); anti-P2RY1 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Reacts with the mouse and rat P2Y1 receptor proteins. On Western blots, a strong clear band ~63kD is exhibited. This molecular weight corresponds to a published report of the P2Y1 receptor; however, other publications have described this protein at 40 and 42kD. Reactivity is confirmed with mouse brain homogenates. Species sequence homology: Human and bovine.
• Purity/Purification: Purified; Purified by epitope affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.

• Applicable Applications for anti-P2RY1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot and ELISA., Recommended Dilution:, Western Blot: 1-3ug/ml, ELISA: 1ug/ml, Optimal dilutions to be determined by the researcher., Positive Control:, Mouse brain homogenates.
• Immunogen: Synthetic peptide derived from the intracellular C-terminal region of the human P2Y1 receptor protein.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot analysis of mouse brain homogenates MBS618721.)

Related Product Information for anti-P2RY1 antibody

The P2 purinoreceptor family consists of two distinct classes: the P2X ligand-gated ion channels, and the P2Y G-protein coupled receptors (GPCR). Eleven subtypes of P2Y receptors have been identified; five are recognized in mammalian species. P2Y receptors are activated by extracellular adenine (ATP) and uridine (UTP) nucleotides. Binding of adenine or uridine to the P2Y receptor triggers a conformational change and the activation of the associated G protein, which induces

Product Categories/Family for anti-P2RY1 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 3766281
• NCBI GeneID: 5028
• UniProt Accession #: P47900
• Molecular Weight: 42,072 Da
• NCBI Official Full Name: P2Y1 receptor
• NCBI Official Synonym Full Names: purinergic receptor P2Y, G-protein coupled, 1
• NCBI Official Symbol: P2RY1
• NCBI Official Synonym Symbols: P2Y1
• NCBI Protein Information: P2Y purinoceptor 1; ATP receptor; OTTHUMP00000216247; platelet ADP receptor; P2 purinoceptor subtype Y1
• UniProt Protein Name: P2Y purinoceptor 1
• Protein Family: P2Y purinoceptor
• UniProt Gene Name: P2RY1
• UniProt Entry Name: P2RY1_HUMAN

NCBI Description

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq]

Uniprot Description

P2RY1: Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q25.2

Cellular Component: postsynaptic membrane; cell surface; mitochondrion; integral to plasma membrane; basolateral plasma membrane; dendrite; apical plasma membrane; plasma membrane

Molecular Function: ATP-activated nucleotide receptor activity; protein binding; purinergic nucleotide receptor activity, G-protein coupled; protein heterodimerization activity; receptor activity; A1 adenosine receptor binding; ADP binding; ATP binding; ADP-activated nucleotide receptor activity

Biological Process: platelet activation; eating behavior; regulation of vasodilation; positive regulation of hormone secretion; positive regulation of inositol trisphosphate biosynthetic process; sensory perception of pain; negative regulation of binding; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; response to mechanical stimulus; positive regulation of transcription from RNA polymerase II promoter; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of ion transport; positive regulation of protein amino acid phosphorylation; regulation of receptor activity; G-protein signaling, adenylate cyclase inhibiting pathway; blood coagulation; adenosine receptor signaling pathway; aging