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Immunohistochemistry (IHC) (Anti-P2RY14 / P2Y14 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Rabbit P2RY14 / GPR105 Polyclonal Antibody | anti-P2RY14 antibody

Rabbit Polyclonal to Human P2RY14 / GPR105

Gene Names
P2RY14; P2Y14; BPR105; GPR105
Reactivity
Human
Predicted Reactivity: Monkey, Mouse (at least 90% immunogen sequence identity)
Applications
Immunohistochemistry
Purity
Immunoaffinity Purified
Synonyms
P2RY14 / GPR105; Polyclonal Antibody; Rabbit Polyclonal to Human P2RY14 / GPR105; Anti-P2RY14 / GPR105 Antibody (Extracellular Domain) IHC-plus; P2RY14; G-protein coupled receptor 105; p2Y purinoceptor 14; p2Y(14) receptor; p2Y14 receptor; UDP-glucose receptor; p2Y14; VTR 15-20 receptor; G protein-coupled receptor 105; GPR105; KIAA0001; p2RY14; Human P2RY14; anti-P2RY14 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Predicted Reactivity: Monkey, Mouse (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Specificity
Human P2RY14 / P2Y14. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
338
Applicable Applications for anti-P2RY14 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes
IHC-P (10 ug/ml)
Target Species
Human
Immunogen Description
Synthetic 16 amino acid peptide from 2nd extracellular domain of human P2RY14 / P2Y14. Percent identity with other species by BLAST analysis: Human (100%); Monkey, Marmoset, Mouse (94%); Rat, Hamster, Panda, Dog, Bat, Rabbit, Pig (88%); Bovine, Horse.
Immunogen Type
Synthetic peptide
Immunogen
P2RY14 / GPR105 antibody was raised against synthetic 16 amino acid peptide from 2nd extracellular domain of human P2RY14 / P2Y14. Percent identity with other species by BLAST analysis: Human (100%); Monkey, Marmoset, Mouse (94%); Rat, Hamster, Panda, Dog, Bat, Rabbit, Pig (88%); Bovine, Horse (81%).
Antigen Modification
Extracellular Domain
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-P2RY14 / P2Y14 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-P2RY14 / P2Y14 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Related Product Information for anti-P2RY14 antibody
GPR105 is a Sugar-Sensing Receptor. GPR105 is a G-protein-coupled receptor identifying a quiescent, primitive population of hematopoietic cells restricted to bone marrow. GPC105 has been suggested to mediates primitive cell responses to specific hematopoietic microenvironments and extends the known immune system functions of P2Y receptors to the stem cell level.
Product Categories/Family for anti-P2RY14 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
38,971 Da
NCBI Official Full Name
P2Y purinoceptor 14
NCBI Official Synonym Full Names
purinergic receptor P2Y, G-protein coupled, 14
NCBI Official Symbol
P2RY14
NCBI Official Synonym Symbols
P2Y14; BPR105; GPR105
NCBI Protein Information
P2Y purinoceptor 14; P2Y14 receptor; UDP-glucose receptor; G protein-coupled receptor 105; G-protein coupled receptor 105; G protein coupled receptor for UDP-glucose
UniProt Protein Name
P2Y purinoceptor 14
Protein Family
UniProt Gene Name
P2RY14
UniProt Synonym Gene Names
GPR105; KIAA0001; P2Y14
UniProt Entry Name
P2Y14_HUMAN

NCBI Description

The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

P2RY14: Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 3q24-q25.1

Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: UDP-activated nucleotide receptor activity; purinergic nucleotide receptor activity, G-protein coupled

Biological Process: G-protein coupled receptor protein signaling pathway

Research Articles on P2RY14

Similar Products

Product Notes

The P2RY14 p2ry14 (Catalog #AAA243651) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human P2RY14 / GPR105 reacts with Human Predicted Reactivity: Monkey, Mouse (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's P2RY14 / GPR105 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin). IHC-P (10 ug/ml). Researchers should empirically determine the suitability of the P2RY14 p2ry14 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "P2RY14 / GPR105, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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