Rabbit p23/PTGES3 Polyclonal Antibody | anti-PTGES3 antibody

Anti-p23/PTGES3 Antibody

Cat. Num. AAA1752872

• Gene Names: PTGES3; P23; TEBP; cPGES
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, ELISA
• Purity: Immunogen Affinity Purified
• Synonyms: p23/PTGES3; Polyclonal Antibody; Anti-p23/PTGES3 Antibody; Prostaglandin E synthase 3; Cytosolic prostaglandin E2 synthase; Cpges; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23; PTGES3; P23; TEBP; anti-PTGES3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: No cross reactivity with other proteins.
• Purity/Purification: Immunogen Affinity Purified
• Form/Format: Lyophilized; Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Sequence Length: 160

• Applicable Applications for anti-PTGES3 antibody: Western Blot (WB), Direct ELISA (EIA)
• Application Notes: WB: 0.1-0.25ug/mL; Direct ELISA: 0.1-0.5ug/mL; Tested Species: In-house tested species with positive results. Other applications have not been tested.
• Immunogen: E. coli-derived human p23/PTGES3 recombinant protein (Position: M1-K79).
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500mug/ml.
• Relevant Detection Systems: MyBioSource recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (MBS176460) for Western blot.
• Preparation and Storage: Store at -20 degree C for one year. After reconstitution, store at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Related Product Information for anti-PTGES3 antibody

Description: Rabbit IgG polyclonal antibody for p23/PTGES3 detection. Tested with WB, Direct ELISA in Human; Mouse; Rat.

Background: Prostaglandin E synthase 3 (cytosolic) is an enzyme that in humans is encoded by the PTGES3 gene. It is mapped to 12q13.3; 12. This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes.

References

1. Weaver AJ, Sullivan WP, Felts SJ, et al. (2000). "Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone". J. Biol. Chem. 275 (30): 23045-23052. 2. Tanioka T, Nakatani Y, Semmyo N, et al. (2000). "Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis". J. Biol. Chem. 275 (42): 32775-32782. 3. Dittmar KD, Pratt WB (1997). "Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation". J. Biol. Chem. 272 (20): 13047-13054.

NCBI and Uniprot Product Information

• NCBI GI #: 23308579
• NCBI GeneID: 10728
• NCBI Accession #: NP_006592.3
• NCBI GenBank Nucleotide #: NP_006592.3
• UniProt Accession #: Q15185
• NCBI Official Full Name: prostaglandin E synthase 3 isoform a
• NCBI Official Synonym Full Names: prostaglandin E synthase 3
• NCBI Official Symbol: PTGES3
• NCBI Official Synonym Symbols: P23; TEBP; cPGES
• NCBI Protein Information: prostaglandin E synthase 3
• UniProt Protein Name: Prostaglandin E synthase 3
• Protein Family: Prostaglandin E synthase
• UniProt Gene Name: PTGES3
• UniProt Synonym Gene Names: P23; TEBP; cPGES
• UniProt Entry Name: TEBP_HUMAN

NCBI Description

This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016]

Uniprot Description

TEBP: Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Belongs to the p23/wos2 family.

Protein type: Transferase; Isomerase; Chaperone; Nuclear receptor co-regulator; EC 5.3.99.3

Chromosomal Location of Human Ortholog: 12q13.3|12

Cellular Component: nucleoplasm; chromosome, telomeric region; telomerase holoenzyme complex; cytoplasm; nucleus; cytosol

Molecular Function: telomerase activity; protein binding; unfolded protein binding; prostaglandin-E synthase activity

Biological Process: RNA-dependent DNA replication; cyclooxygenase pathway; arachidonic acid metabolic process; prostaglandin biosynthetic process; signal transduction; telomere maintenance