Rabbit OXA1L Polyclonal Antibody | anti-OXA1L antibody

OXA1L Polyclonal Antibody

Cat. Num. AAA3011491

• Gene Names: OXA1L; OXA1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: OXA1L; Polyclonal Antibody; OXA1L Polyclonal Antibody; Mitochondrial inner membrane protein OXA1L; Has; OXA1Hs; Oxidase assembly 1-like protein; OXA1-like protein; anti-OXA1L antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: OXA1L polyclonal antibody detects endogenous levels of OXA1L protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 495

• Applicable Applications for anti-OXA1L antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:10-1:100
• Immunogen: Recombinant full length Human OXA1L.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of OXA1L polyclonal antibody)

Related Product Information for anti-OXA1L antibody

OXA1L (oxidase (cytochrome c) assembly 1-like), also known as OXA1, is a 435 mitochondrial inner membrane protein belonging to the evolutionarily conserved Oxa1/Alb3/YidC protein family. Members of the Oxa1/Alb3/YidC protein family are involved in the biogenesis of membrane proteins in mitochondria, chloroplasts and bacteria. Existing as three isoforms produced by alternative splicing events, OXA1L is required for the insertion of integral membrane proteins into the mitochondrial inner membrane. OXA1L is essential for the activity and assembly of cytochrome oxidase and for the correct biogenesis of F(1)F(o)-ATP synthase and NADH: ubiquinone oxidoreductase. Mutations in the gene encoding OXA1L might be involved in the pathology of combined enzymatic deficiencies of the oxidative phosphorylation (OXPHOS) system.

NCBI and Uniprot Product Information

• NCBI GI #: 2546979
• NCBI GeneID: 5018
• UniProt Accession #: Q15070
• Molecular Weight: ~ 42kDa
• NCBI Official Full Name: OXA1L
• NCBI Official Synonym Full Names: OXA1L mitochondrial inner membrane protein
• NCBI Official Symbol: OXA1L
• NCBI Official Synonym Symbols: OXA1
• NCBI Protein Information: mitochondrial inner membrane protein OXA1L
• UniProt Protein Name: Mitochondrial inner membrane protein OXA1L
• Protein Family: Mitochondrial inner membrane protein
• UniProt Gene Name: OXA1L
• UniProt Synonym Gene Names: OXA1-like protein
• UniProt Entry Name: OXA1L_HUMAN

NCBI Description

This gene encodes an evolutionarily conserved protein that is localized to the inner mitochondrial membrane. The encoded protein is essential for the translocation of the N-terminal tail of subunit 2 of cytochrome c oxidase, and is involved in the assembly of the cytochrome c oxidase and ATPase complexes of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2016]

Uniprot Description

OXA1L: Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria. Belongs to the OXA1/ALB3/YidC family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: mitochondrial membrane; mitochondrial respiratory chain; mitochondrion; protein complex

Molecular Function: protein binding; protein homodimerization activity

Biological Process: aerobic respiration; mitochondrial proton-transporting ATP synthase complex assembly; mitochondrial respiratory chain complex I assembly; negative regulation of ATPase activity; negative regulation of oxidoreductase activity; protein complex assembly; protein insertion into membrane; protein tetramerization