Rabbit OST-beta Polyclonal Antibody | anti-OST-beta antibody
OST-beta Antibody HRP Conjugated
Gene Names
SLC51B; OSTB; OSTBETA
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Purity
Purified by Protein A
Synonyms
OST-beta; Polyclonal Antibody; OST-beta Antibody HRP Conjugated; organic solute transporter beta Ostbeta; Organic solute transporter subunit beta; Ostbeta; Ost beta; OSTB; OSTB_HUMAN; anti-OST-beta antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified by Protein A
Form/Format
10mM Tris Buffered Saline containing 1% BSA, 50% glycerol and 0.09% Gentamicin.
Concentration
1mgml (varies by lot)
Applicable Applications for anti-OST-beta antibody
Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
Application Notes
WB: 1:100-1000
IHC: 1:100-500
IHC: 1:100-500
Conjugation
HRP
Immunogen
KLH conjugated synthetic peptide derived from human OST-beta
Preparation and Storage
Store at 4 degree C for 12 months.
Related Product Information for anti-OST-beta antibody
The heteromeric transporter OST Alpha OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OST Alpha OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha to localize to the plasma membrane. Coexpression of OST Alpha and OST Beta is also required to convert the OST Alpha subunit to a mature glycosylated endoglycosidase H-resistant form, suggesting that co-expression facilitates trafficking of OST Alpha through the golgi apparatus. Though widely expressed, OST Beta is present at highest levels in ileum.
Product Categories/Family for anti-OST-beta antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
14,346 Da
NCBI Official Full Name
organic solute transporter subunit beta
NCBI Official Synonym Full Names
solute carrier family 51, beta subunit
NCBI Official Symbol
SLC51B
NCBI Official Synonym Symbols
OSTB; OSTBETA
NCBI Protein Information
organic solute transporter subunit beta; OST-beta; organic solute transporter beta subunit; solute carrier family 51 subunit beta
UniProt Protein Name
Organic solute transporter subunit beta
UniProt Gene Name
SLC51B
UniProt Synonym Gene Names
OSTB; OST-beta
UniProt Entry Name
OSTB_HUMAN
Uniprot Description
Ostb: Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities. Belongs to the OST-beta family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q22.31
Cellular Component: protein complex; plasma membrane; integral to membrane
Molecular Function: protein heterodimerization activity; transporter activity
Biological Process: bile acid and bile salt transport; positive regulation of protein amino acid glycosylation; regulation of protein stability
Research Articles on OST-beta
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Product Notes
The OST-beta slc51b (Catalog #AAA9460936) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The OST-beta Antibody HRP Conjugated reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's OST-beta can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). WB: 1:100-1000 IHC: 1:100-500. Researchers should empirically determine the suitability of the OST-beta slc51b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "OST-beta, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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