Rabbit anti-Human OSMR Polyclonal Antibody | anti-OSMR antibody

OSMR antibody

Cat. Num. AAA9408037

• Gene Names: OSMR; OSMRB; PLCA1
• Reactivity: Human
• Applications: Western Blot
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: OSMR; Polyclonal Antibody; OSMR antibody; OSMRB; PLCA1; anti-OSMR antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total OSMR antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 342

• Applicable Applications for anti-OSMR antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500 - 1:2000
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human OSMR.
• Target Name: OSMR
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using OSMR antibody.)

Related Product Information for anti-OSMR antibody

This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-OSMR antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 270288820
• NCBI GeneID: 9180
• NCBI Accession #: NP_001161827.1
• NCBI GenBank Nucleotide #: NM_001168355.1
• UniProt Accession #: Q99650; Q6P4E8; Q96QJ6
• Molecular Weight: 39,504 Da
• NCBI Official Full Name: oncostatin-M-specific receptor subunit beta isoform 2
• NCBI Official Synonym Full Names: oncostatin M receptor
• NCBI Official Symbol: OSMR
• NCBI Official Synonym Symbols: OSMRB; PLCA1
• NCBI Protein Information: oncostatin-M-specific receptor subunit beta
• UniProt Protein Name: Oncostatin-M-specific receptor subunit beta
• Protein Family: Oncostatin-M-specific receptor
• UniProt Gene Name: OSMR
• UniProt Synonym Gene Names: OSMRB; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB
• UniProt Entry Name: OSMR_HUMAN

NCBI Description

This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Uniprot Description

OSMR: Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. Defects in OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1); also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Belongs to the type I cytokine receptor family. Type 2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: oncostatin-M receptor complex

Molecular Function: oncostatin-M receptor activity; growth factor binding

Biological Process: positive regulation of acute inflammatory response; response to cytokine stimulus; positive regulation of cell proliferation

Disease: Amyloidosis, Primary Localized Cutaneous, 1