Rabbit anti-Human, Mouse ORC6L Polyclonal Antibody | anti-ORC6L antibody

ORC6L Antibody

Cat. Num. AAA9419094

• Gene Names: ORC6; ORC6L
• Reactivity: Human, Mouse
• Applications: Western Blot
• Synonyms: ORC6L; Polyclonal Antibody; ORC6L Antibody; ORC6; anti-ORC6L antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: ORC6L Antibody detects endogenous levels of total ORC6L
• Form/Format: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0mg/mL (varies by lot)
• Sequence Length: 252

• Applicable Applications for anti-ORC6L antibody: Western Blot (WB)
• Application Notes: Western Blot: 1:1000-3000
• Immunogen: A synthesized peptide derived from human ORC6L
• Immunogen Type: Peptide
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis ORC6L using COLO205 whole cell lysates)

Product Categories/Family for anti-ORC6L antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 7657427
• NCBI GeneID: 23594
• NCBI Accession #: NP_055136.1
• NCBI GenBank Nucleotide #: NM_014321.3
• UniProt Accession #: Q9Y5N6; B3KN89
• Molecular Weight: 28,107 Da
• NCBI Official Full Name: origin recognition complex subunit 6
• NCBI Official Synonym Full Names: origin recognition complex subunit 6
• NCBI Official Symbol: ORC6
• NCBI Official Synonym Symbols: ORC6L
• NCBI Protein Information: origin recognition complex subunit 6
• UniProt Protein Name: Origin recognition complex subunit 6
• UniProt Gene Name: ORC6
• UniProt Synonym Gene Names: ORC6L
• UniProt Entry Name: ORC6_HUMAN

NCBI Description

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]

Uniprot Description

ORC6L: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4. Belongs to the ORC6 family.

Protein type: DNA replication

Chromosomal Location of Human Ortholog: 16q12

Cellular Component: actin cytoskeleton; membrane; nuclear origin of replication recognition complex; nucleoplasm; nucleus; origin recognition complex

Molecular Function: DNA replication origin binding; protein binding

Biological Process: DNA replication; DNA replication initiation; G1/S transition of mitotic cell cycle

Disease: Meier-gorlin Syndrome 3