Western Blot (WB)
(Host: RabbitTarget Name: ORC6Sample Type: Thyroid Tumor lysatesAntibody Dilution: 1.0ug/ml)
Rabbit ORC6 Polyclonal Antibody | anti-ORC6 antibody
ORC6 Antibody - N-terminal region
Western Blot (WB)
(Host: RabbitTarget Name: ORC6Sample Type: Thyroid Tumor lysatesAntibody Dilution: 1.0ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: ORC6Sample Type: Thyroid Tumor lysatesAntibody Dilution: 1.0ug/ml)
Target Description: The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. ORC6L is a subunit of the ORC complex. It has been shown that this protein and and ORC1L are loosely associated with the core complex consisting of ORC2L, -3L, -4L and -5L. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.
NCBI and Uniprot Product Information
NCBI Description
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]
Uniprot Description
ORC6L: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4. Belongs to the ORC6 family.
Protein type: DNA replication
Chromosomal Location of Human Ortholog: 16q12
Cellular Component: nucleoplasm; membrane; plasma membrane; nuclear origin of replication recognition complex; nucleus; origin recognition complex
Molecular Function: protein binding; DNA binding
Biological Process: mitotic cell cycle; DNA replication; DNA-dependent DNA replication; G1/S transition of mitotic cell cycle
Disease: Meier-gorlin Syndrome 3
Research Articles on ORC6
Similar Products
Product Notes
The ORC6 orc6 (Catalog #AAA3212002) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ORC6 Antibody - N-terminal region reacts with Cow, Dog, Horse, Human, Rabbit and may cross-react with other species as described in the data sheet. AAA Biotech's ORC6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the ORC6 orc6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: KAEEYLRLSR VKCVGLSART TETSSAVMCL DLAASWMKCP LDRAYLIKLS. It is sometimes possible for the material contained within the vial of "ORC6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
