Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with ORAI1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Rabbit ORAI1 Polyclonal Antibody | anti-ORAI1 antibody
ORAI1 Antibody (Center)
WB~~1:1000
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with ORAI1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with ORAI1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Western Blot (WB)
(Western blot analysis of ORAI1 Antibody (Center) in A375 cell line and mouse testis tissue lysates (35ug/lane). ORAI1 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of ORAI1 Antibody (Center) in A375 cell line and mouse testis tissue lysates (35ug/lane). ORAI1 (arrow) was detected using the purified Pab.)
Calloway,N. Biochemistry 49 (6), 1067-1071 (2010)
McCarl,C.A. J. Allergy Clin. Immunol. 124 (6), 1311-1318 (2009)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]
Uniprot Description
ORAI1: Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. Interacts with STIM1 and STIM2. Interacts with EFCAB4B/CRACR2A; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with EFCAB4B/CRACR2A and STIM1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Belongs to the Orai family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: protein complex; membrane; integral to plasma membrane
Molecular Function: calmodulin binding; identical protein binding; protein binding; store-operated calcium channel activity
Biological Process: immune system process; regulation of calcium ion transport; positive regulation of calcium ion transport; blood coagulation
Disease: Myopathy, Tubular Aggregate, 2; Immunodeficiency 9
Research Articles on ORAI1
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Product Notes
The ORAI1 orai1 (Catalog #AAA9204408) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 145-173. The ORAI1 Antibody (Center) reacts with Human, mouse (Predicted Reactivity: Chicken, Zebrafish, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's ORAI1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB). IHC~~1:50~100 WB~~1:1000. Researchers should empirically determine the suitability of the ORAI1 orai1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ORAI1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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