Rabbit anti-Human Opioid Receptor, mu, aa391-398 Polyclonal Antibody | anti-OPRM1 antibody

Opioid Receptor, mu, CT, aa391-398 (MOR1)

Cat. Num. AAA642183

• Gene Names: OPRM1; MOP; MOR; LMOR; MOR1; OPRM; M-OR-1
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunocytochemistry
• Purity: Highly Purified; Purified by precipitation, dialysis and chromatography.
• Synonyms: Opioid Receptor; mu; aa391-398; Polyclonal Antibody; CT; aa391-398 (MOR1); Anti -Opioid Receptor; anti-OPRM1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Specific for the COOH terminal of the mu opioid receptor.
• Purity/Purification: Highly Purified; Purified by precipitation, dialysis and chromatography.
• Form/Format: Supplied as a liquid in PBS, 10mg/ml BSA, 40% glycerol.

• Applicable Applications for anti-OPRM1 antibody: ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC)
• Application Notes: Suitable for use in ELISA, Western Blot, and Immunocytochemistry.; Dilution: ELISA: 20ug/ml; Western Blot: 50ug/ml. Please note that this antibody requires a low dilution for Western Blot.; Immunocytochemistry: 20ug/ml. This antibody has been found to stain specific cells in various regions of PLP fixed rat brain sections known to express the mu opioid receptor using ABC techniques.
• Immunogen: Peptide analogue of the carboxyl terminal of the mu opioid receptor covalently attached onto a carrier protein.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-OPRM1 antibody

Opioid receptors are G-protein coupled receptors. Most actions of exogenous opioids, such as morphine, are mediated through the mu-opioid receptor, including analgesia, tolerance and reward. In general, opioids modulate numerous central and peripheral processes including pain perception, neuroendocrine secretion and the immune response. The opioid signal is transduced from receptors through G proteins to various different effectors. Subsequent to G protein activation, several effectors are known to orchestrate the opioid signal. For example, activation of opioid receptors increases phosphatidyl-inositol turnover, activates K+ channels and reduces adenylyl cyclase and Ca++ channel activities.

Product Categories/Family for anti-OPRM1 antibody

Antibodies; Abs to Opioid Receptors; Agonists

NCBI and Uniprot Product Information

• NCBI GI #: 119568090
• NCBI GeneID: 4988
• UniProt Accession #: P35372; Q12930; Q4VWM1; Q4VWM2; B0FXJ1; B2R9S7; B8Q1L7; B8Q1L8; B8Q1L9; E7EWZ3; G8XRH6; G8XRH8
• Molecular Weight: 44,779 Da
• NCBI Official Full Name: opioid receptor, mu 1, isoform CRA_b
• NCBI Official Synonym Full Names: opioid receptor, mu 1
• NCBI Official Symbol: OPRM1
• NCBI Official Synonym Symbols: MOP; MOR; LMOR; MOR1; OPRM; M-OR-1
• NCBI Protein Information: mu-type opioid receptor; mu opiate receptor; mu opioid receptor hMOR-1a; micro opioid receptor isoform hMOR-1A2
• UniProt Protein Name: Mu-type opioid receptor
• Protein Family: Mu-type opioid receptor
• UniProt Gene Name: OPRM1
• UniProt Synonym Gene Names: MOR1; M-OR-1; MOR-1; MOP; hMOP
• UniProt Entry Name: OPRM_HUMAN

NCBI Description

This gene encodes one of three opioid receptors. The mu opioid receptor is the principal target of endogenous opioid peptides and opioid analgesic agents such a s beta-endorphn and enkephalins. The NM_001008503.1:c.118A>G allele had been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Uniprot Description

MOR-1: a Gi-protein-coupled receptor for beta-endorphin, morphine and other opiates. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Ligand-binding inactivates adenylyl cyclase, and activates a variety of G-beta-gamma-dependent pathways including the MAPK and the PI3K/Akt cascades. Two splice-variant isoforms have been described.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q24-q25

Cellular Component: dendrite cytoplasm; Golgi apparatus; neuron projection; focal adhesion; integral to plasma membrane; endoplasmic reticulum; plasma membrane; perikaryon; sarcolemma; lipid raft

Molecular Function: voltage-gated calcium channel activity; G-protein coupled receptor activity; protein domain specific binding; neuropeptide binding; protein binding; G-protein beta-subunit binding; G-protein alpha-subunit binding; filamin binding; beta-endorphin receptor activity

Biological Process: response to food; positive regulation of neurogenesis; positive regulation of nitric oxide biosynthetic process; wound healing; negative regulation of nitric oxide biosynthetic process; cellular response to stress; negative regulation of adenylate cyclase activity; locomotory behavior; response to lipopolysaccharide; behavioral response to ethanol; response to cocaine; sensory perception of pain; negative regulation of cell proliferation; synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; elevation of cytosolic calcium ion concentration; neuropeptide signaling pathway; positive regulation of appetite; sensory perception; reduction of cytosolic calcium ion concentration; opioid receptor, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of sensory perception of pain; regulation of excitatory postsynaptic membrane potential; dopamine receptor, adenylate cyclase activating pathway; acute inflammatory response to antigenic stimulus

Disease: Epilepsy, Idiopathic Generalized