Rabbit Oncostatin M Polyclonal Antibody | anti-OSM antibody

Oncostatin M antibody

Cat. Num. AAA535131

• Reactivity: Human oncostatin M
• Applications: ELISA, Western Blot
• Synonyms: Oncostatin M; Polyclonal Antibody; Oncostatin M antibody; Polyclonal Oncostatin M; Anti-Oncostatin M; OSM; anti-OSM antibody

• Host: Rabbit
• Reactivity: Human oncostatin M
• Clonality: Polyclonal
• Specificity: Human oncostatin M
• Form/Format: Lyophilized from 0.5x PBS, pH 7.4. Reconstitute in sterile water to a concentration of > 0.2 mg/ml.
• Sequence Length: 252

• Applicable Applications for anti-OSM antibody: ELISA (EIA), Inhibition, Western Blot (WB)
• Application Notes: ELISA: 0.5-2 ug/ml; Inhibition: 0.1-0.175 ug/ml; WB: 0.1-0.2 ug/ml
• Biological Significance: Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activate T cells, monocytes and Kaposi?s sarcoma cells, OSH can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi?s sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL6, and CNTF. Human OSM is active on Mouse cells.
• Immunogen: Oncostatin M antibody was raised in rabbit using highly pure recombinant human oncostatin M as the immunogen.
• Preparation and Storage: Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-OSM antibody

Affinity purified Rabbit polyclonal Oncostatin M antibody

Product Categories/Family for anti-OSM antibody

Cytokines & Growth Factors; Purified Polyclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 10092621
• NCBI GeneID: 5008
• NCBI Accession #: NP_065391.1
• NCBI GenBank Nucleotide #: NM_020530.4
• UniProt Accession #: P13725; Q6FHP8; Q9UCP6
• Molecular Weight: 23.9 kDa (predicted detection band MW)
• NCBI Official Full Name: oncostatin-M preproprotein
• NCBI Official Synonym Full Names: oncostatin M
• NCBI Official Symbol: OSM
• NCBI Protein Information: oncostatin-M
• UniProt Protein Name: Oncostatin-M
• Protein Family: Oncostatin
• UniProt Gene Name: OSM
• UniProt Synonym Gene Names: OSM
• UniProt Entry Name: ONCM_HUMAN

NCBI Description

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. [provided by RefSeq, Jul 2008]

Uniprot Description

OSM: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. Belongs to the LIF/OSM family.

Protein type: Secreted, signal peptide; Secreted; Cytokine

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: extracellular space

Molecular Function: growth factor activity; oncostatin-M receptor binding; cytokine activity

Biological Process: multicellular organismal development; negative regulation of hormone secretion; tyrosine phosphorylation of Stat3 protein; tyrosine phosphorylation of Stat5 protein; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system development; negative regulation of cell proliferation; cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; behavioral response to pain; positive regulation of MAPKKK cascade; positive regulation of acute inflammatory response; response to heat; regulation of growth; positive regulation of cell division; positive regulation of cell proliferation; negative regulation of meiosis; tyrosine phosphorylation of Stat1 protein; positive regulation of transcription from RNA polymerase II promoter; immune response