Immunohistochemistry (IHC)
(Immunochemical staining of human OMGP in human stomach with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)
Rabbit anti-Human OMGP Polyclonal Antibody | anti-OMG antibody
Anti-OMGP Antibody, Rabbit Polyclonal
Gene Names
OMG; OMGP
Reactivity
Human
Applications
ELISA, Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
OMGP; Polyclonal Antibody; Anti-OMGP Antibody; Rabbit Polyclonal; OMGP Antibody; Rabbit PAb; Antigen Affinity Purified; oligodendrocyte myelin glycoprotein; anti-OMG antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human OMGP
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-OMG antibody
ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P)
Application Notes
ELISA: 1:5000-1:10,000
IHC-P: 1:500-1:2000
IHC-P: 1:500-1:2000
Immunogen
Recombinant Human OMGP protein
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with purified, recombinant Human OMGP (rh OMGP). OMGP specific IgG was purified by Human OMGP affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human OMGP in human stomach with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)
Immunohistochemistry (IHC)
(Immunochemical staining of human OMGP in human stomach with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)
Related Product Information for anti-OMG antibody
Oligodendrocyte-myelin glycoprotein, also known as OMG and OMGP, is a cell membrane protein that contains eight LRR (leucine-rich) repeats. OMG/OMGP is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes in the central nervous system (CNS). OMG/OMGP is a cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system. OMG/OMGP play roles in both the developing and adult central nervous system. OMG/OMGP participates in growth cone collapse and inhibition of neurite outgrowth through its interaction with NgR, the receptor for Nogo. This function requires its leucine-rich repeat domain, a highly conserved region in OMgp during mammal evolution. OMG/OMGP leucine-rich repeat domain is also implicated in the inhibition of cell proliferation. OMG/OMGP may also be involved in the formation and maintenance of myelin sheaths. Cell proliferation, neuronal sprouting, and myelination are crucial processes involved in brain development and regeneration after injury.
References
Viskochil D., et al., (1991), The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene. Mol. Cell. Biol. 11:906-912.Mikol D.D., et al., (1990), The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate.J. Cell Biol. 110:471-479.Mikol D.D., et al., (1990), Structure and chromosomal localization of the gene for the oligodendrocyte-myelin glycoprotein.J. Cell Biol. 111:2673-2679.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
49,608 Da
NCBI Official Full Name
oligodendrocyte-myelin glycoprotein
NCBI Official Synonym Full Names
oligodendrocyte myelin glycoprotein
NCBI Official Symbol
OMG
NCBI Official Synonym Symbols
OMGP
NCBI Protein Information
oligodendrocyte-myelin glycoprotein
UniProt Protein Name
Oligodendrocyte-myelin glycoprotein
Protein Family
UniProt Gene Name
OMG
UniProt Synonym Gene Names
OMGP
UniProt Entry Name
OMGP_HUMAN
Uniprot Description
OMG: Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.
Protein type: Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: plasma membrane
Molecular Function: identical protein binding
Biological Process: nerve growth factor receptor signaling pathway; neurite regeneration; negative regulation of axonogenesis; cell adhesion; regulation of axonogenesis; regulation of collateral sprouting of intact axon in response to injury
Research Articles on OMG
Similar Products
Product Notes
The OMG omg (Catalog #AAA8102044) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-OMGP Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's OMGP can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P). ELISA: 1:5000-1:10,000 IHC-P: 1:500-1:2000. Researchers should empirically determine the suitability of the OMG omg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "OMGP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
