Immunofluorescence (IF)
(Immunofluorescence analysis of U-2 OS cells using OBSCN Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.)
Rabbit OBSCN Polyclonal Antibody | anti-OBSCN antibody
OBSCN Polyclonal Antibody
Immunofluorescence (IF)
(Immunofluorescence analysis of U-2 OS cells using OBSCN Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.)
Immunofluorescence (IF)
(Immunofluorescence analysis of U-2 OS cells using OBSCN Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.)
Immunofluorescence (IF)
(Immunofluorescence analysis of Rat heart using OBSCN Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.)
Immunofluorescence (IF)
(Immunofluorescence analysis of Rat heart using OBSCN Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.)
Immunofluorescence (IF)
(Immunofluorescence analysis of Mouse heart using OBSCN Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.)
Immunofluorescence (IF)
(Immunofluorescence analysis of Mouse heart using OBSCN Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.)
NCBI and Uniprot Product Information
NCBI Description
The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
OBSCN: a Ca(2+)/calmodulin-dependent protein kinase of the Trio family. A giant protein with one Rho GEF domain, one PH domain and two kinase domains. Expressed in skeletal and cardiac muscle, concentrating around Z-disks and M-lines of striated muscle. Binds ankyrin 1 interacts with sarcomeric myosin. May play a critical role in its ability to assemble into A bands in striated muscle.
Protein type: CAMK group; EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Trio family
Chromosomal Location of Human Ortholog: 1q42.13
Cellular Component: cytosol; M band; myofibril; nuclear body; plasma membrane; sarcolemma; Z disc
Molecular Function: ankyrin binding; ATP binding; calmodulin binding; guanyl-nucleotide exchange factor activity; metal ion binding; protein binding; protein serine/threonine kinase activity; Rho guanyl-nucleotide exchange factor activity; structural constituent of muscle; titin binding
Biological Process: G-protein coupled receptor signaling pathway; multicellular organism development; positive regulation of apoptosis; protein amino acid phosphorylation; regulation of molecular function; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; sarcomere organization
Research Articles on OBSCN
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Product Notes
The OBSCN obscn (Catalog #AAA2566128) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The OBSCN Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's OBSCN can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF). IF: 1:50-1:200. Researchers should empirically determine the suitability of the OBSCN obscn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "OBSCN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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