Western Blot (WB)
(Western blot analysis of OAZ1 Antibody (N-term) in mouse heart tissue lysates (35ug/lane). OAZ1 (arrow) was detected using the purified Pab.)
Rabbit anti-Human, Mouse OAZ1 Polyclonal Antibody | anti-OAZ1 antibody
OAZ1, NT (Ornithine Decarboxylase Antizyme 1, ODC-Az, OAZ, AZI, MGC138338)
Purified by ammonium sulfate precipitation
Purified by ammonium sulfate precipitation
Dilution: ELISA: 1:1000
Western Blot: 1:50-1:100
Immunohistochemistry (FFPE): 1:50-1:100
Western Blot (WB)
(Western blot analysis of OAZ1 Antibody (N-term) in mouse heart tissue lysates (35ug/lane). OAZ1 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of OAZ1 Antibody (N-term) in mouse heart tissue lysates (35ug/lane). OAZ1 (arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded mouse heart tissue reacted with OAZ1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded mouse heart tissue reacted with OAZ1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
NCBI and Uniprot Product Information
NCBI Description
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase and accelerates its degradation. [provided by RefSeq]
Uniprot Description
OAZ1: Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Belongs to the ODC antizyme family. 1 isoforms of the human protein are produced by ribosomal frameshifting.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cytosol
Molecular Function: protein binding; ornithine decarboxylase inhibitor activity
Biological Process: transport; polyamine biosynthetic process; negative regulation of catalytic activity; positive regulation of protein catabolic process; regulation of amino acid metabolic process
Research Articles on OAZ1
Similar Products
Product Notes
The OAZ1 oaz1 (Catalog #AAA629823) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The OAZ1, NT (Ornithine Decarboxylase Antizyme 1, ODC-Az, OAZ, AZI, MGC138338) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's OAZ1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in ELISA, Western Blot and Immunohistochemistry. Dilution: ELISA: 1:1000 Western Blot: 1:50-1:100 Immunohistochemistry (FFPE): 1:50-1:100. Researchers should empirically determine the suitability of the OAZ1 oaz1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "OAZ1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
