Rabbit anti-Human OAS2 Polyclonal Antibody | anti-OAS2 antibody

OAS2 Antibody

Cat. Num. AAA9507761

• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
• Synonyms: OAS2; Polyclonal Antibody; OAS2 Antibody; anti-OAS2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: OAS2 Antibody detects endogenous levels of OAS2 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 172

• Applicable Applications for anti-OAS2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; ELISA: 1:10000
• Target Modification: Unmodified/Total
• Immunogen: The antiserum was produced against synthesized peptide derived from the N-terminal region of human OAS2.
• Immunogen Range: 61-110
• Preparation and Storage: Store at -20 degree C for 1 year.

Western Blot (WB)

(Western Blot analysis of extracts from HeLa cells using OAS2 Antibody.)

NCBI and Uniprot Product Information

• NCBI GI #: 74229021
• NCBI GeneID: 4939
• NCBI Accession #: NP_001027903.1
• NCBI GenBank Nucleotide #: NM_001032731.1
• UniProt Accession #: P29728; Q6PJ33; Q86XX8; A8K9T1
• Molecular Weight: 82
• NCBI Official Full Name: 2'-5'-oligoadenylate synthase 2 isoform 3
• NCBI Official Synonym Full Names: 2'-5'-oligoadenylate synthetase 2
• NCBI Official Symbol: OAS2
• NCBI Protein Information: 2'-5'-oligoadenylate synthase 2
• UniProt Protein Name: 2'-5'-oligoadenylate synthase 2
• Protein Family: 2'-5'-oligoadenylate synthase
• UniProt Gene Name: OAS2
• UniProt Synonym Gene Names: (2-5')oligo(A) synthase 2; 2-5A synthase 2; p69OAS / p71OAS

NCBI Description

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.